Seroatlas · Human Serome Atlas

LHPP

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Also known as: HDHD2B, LHPP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H008
Gene: LHPP
Ensembl: ENSG00000107902
Chromosome: 10
Canonical length: 270 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables inorganic diphosphate phosphatase activity and protein homodimerization activity. Involved in phosphate-containing compound metabolic process. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q9H008|LHPP
     1  MAPWGKRLAG VRGVLLDISG VLYDSGAGGG TAIAGSVEAV ARLKRSRLKV RFCTNESQKS
    61  RAELVGQLQR LGFDISEQEV TAPAPAACQI LKEQGLRPYL LIHDGVRSEF DQIDTSNPNC
   121  VVIADAGESF SYQNMNNAFQ VLMELEKPVL ISLGKGRYYK ETSGLMLDVG PYMKALEYAC
   181  GIKAEVVGKP SPEFFKSALQ AIGVEAHQAV MIGDDIVGDV GGAQRCGMRA LQVRTGKFRP
   241  SDEHHPEVKA DGYVDNLAEA VDLLLQHADK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LHPP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 389 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 389 nTPM
midbrain: 215 nTPM
hippocampal formation: 129 nTPM
amygdala: 112 nTPM
basal ganglia: 108 nTPM
hypothalamus: 101 nTPM

Single-cell type

late spermatids: 298 nCPM
early spermatids: 212 nCPM
tuft cells: 150 nCPM
oligodendrocytes: 132 nCPM
enterocytes: 94 nCPM
cytotrophoblasts: 84 nCPM

Immune cell

naive B-cell: 44 nTPM
memory B-cell: 41 nTPM
myeloid DC: 36 nTPM
T-reg: 32 nTPM
non-classical monocyte: 29 nTPM
classical monocyte: 29 nTPM

Brain region

white matter: 211 nTPM
medulla oblongata: 180 nTPM
basal ganglia: 166 nTPM
pons: 162 nTPM
midbrain: 151 nTPM
cerebellum: 138 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phosphate-containing compound metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LHPP as an antibody target. Whether an autoantibody or antibody against LHPP could matter depends on whether native LHPP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LHPP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LHPP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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