Seroatlas · Human Serome Atlas

LHB

Lutropin subunit beta

Also known as: CGB4, hLHB, LSH-B, LSHB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01229
Gene
LHB
Ensembl
ENSG00000104826
Chromosome
19
Canonical length
141 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

141 residues, UniProt reviewed canonical sequence.

>P01229|LHB
     1  MEMLQGLLLL LLLSMGGAWA SREPLRPWCH PINAILAVEK EGCPVCITVN TTICAGYCPT
    61  MMRVLQAVLP PLPQVVCTYR DVRFESIRLP GCPRGVDPVV SFPVALSCRC GPCRRSTSDC
   121  GGPKDHPLTC DHPQLSGLLF L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LHB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
4,053 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 4,053 nTPM
  • pancreas: 12 nTPM
  • adrenal gland: 3.9 nTPM
  • testis: 3.5 nTPM
  • stomach: 3.2 nTPM
  • skin: 2.5 nTPM

Single-cell type

  • gonadotrophs: 2,250 nCPM
  • pituitary stem cells: 35 nCPM
  • somatotrophs: 32 nCPM
  • syncytiotrophoblasts: 11 nCPM
  • oocytes: 9.2 nCPM
  • late spermatids: 7.6 nCPM

Immune cell

  • memory CD4 T-cell: 0.2 nTPM
  • T-reg: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebellum: 1.9 nTPM
  • white matter: 1.7 nTPM
  • cerebral cortex: 1.6 nTPM
  • medulla oblongata: 1.6 nTPM
  • pons: 1.6 nTPM
  • hypothalamus: 1.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LHB.

Disease | AllUniProt

Conditions LHB is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 23 with or without anosmia (HH23) MIM:228300

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 94 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Isolated lutropin deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.76
gnomAD pLI
0
gnomAD missense Z
-0.62
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LHB as an antibody target. Whether an autoantibody or antibody against LHB could matter depends on whether native LHB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LHB is annotated as secreted, so native LHB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LHB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LHB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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