LGSN

Protein identityUniProt · HPA

UniProt accession

Q5TDP6

Gene

LGSN

Ensembl

ENSG00000146166

Chromosome

6

Canonical length

509 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a protein with similarity to the GS I members of the glutamine synthetase superfamily. The encoded protein is referred to as a pseudo-glutamine synthetase because it has no glutamine synthesis activity and may function as a chaperone protein. This protein is localized to the lens and may be associated with cataract disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

509 residues, UniProt reviewed canonical sequence.

>Q5TDP6|LGSN
     1  MNNEEDLLQE DSTRDEGNET EANSMNTLRR TRKKVTKPYV CSTEVGETDM SNSNDCMRDS
    61  SQILTPPQLS SRMKHIRQAM AKNRLQFVRF EATDLHGVSR SKTIPAHFFQ EKVSHGVCMP
   121  RGYLEVIPNP KDNEMNNIRA TCFNSDIVLM PELSTFRVLP WADRTARVIC DTFTVTGEPL
   181  LTSPRYIAKR QLSHLQASGF SLLSAFIYDF CIFGVPEILN SKIISFPALT FLNNHDQPFM
   241  QELVDGLYHT GANVESFSSS TRPGQMEISF LPEFGISSAD NAFTLRTGVK EVARKYNYIA
   301  SFFIETGFCD SGILSHSLWD VDRKKNMFCS TSGTEQLTIT GKKWLAGLLK HSAALSCLMA
   361  PSVSCRKRYS KDRKDLKKSV PTTWGYNDNS CIFNIKCHGE KGTRIENKLG SATANPYLVL
   421  AATVAAGLDG LHSSNEVLAG PDESTDFYQV EPSEIPLKLE DALVALEEDQ CLRQALGETF
   481  IRYFVAMKKY ELENEEIAAE RNKFLEYFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGSN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

3.5 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LGSN.

Disease | ImmuneIEDB

Conditions an epitope on LGSN was assayed in.

• lung non-small cell carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.56

gnomAD pLI

0

gnomAD missense Z

-0.55

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

• catalytic activity

Cellular components

• cytoplasm
• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Glutamine synthetase, catalytic domain
• Glutamine synthetase, N-terminal domain
• Glutamine synthetase/guanido kinase, catalytic domain
• Glutamine synthetase, N-terminal domain superfamily
• Glutamine synthetase, catalytic domain

InteractionsUniProt · HPA

Protein binding partners of LGSN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BFSP2
• VIM