Seroatlas · Human Serome Atlas

LGI2

Leucine-rich repeat LGI family member 2

Also known as: FLJ10675, KIAA1916, LGI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N0V4
Gene: LGI2
Ensembl: ENSG00000153012
Chromosome: 4
Canonical length: 545 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Centrosome
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to be involved in inhibitory synapse assembly. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

545 residues, UniProt reviewed canonical sequence.

>Q8N0V4|LGI2
     1  MALRRGGCGA LGLLLLLLGA ACLIPRSAQV RRLARCPATC SCTKESIICV GSSWVPRIVP
    61  GDISSLSLVN GTFSEIKDRM FSHLPSLQLL LLNSNSFTII RDDAFAGLFH LEYLFIEGNK
   121  IETISRNAFR GLRDLTHLSL ANNHIKALPR DVFSDLDSLI ELDLRGNKFE CDCKAKWLYL
   181  WLKMTNSTVS DVLCIGPPEY QEKKLNDVTS FDYECTTTDF VVHQTLPYQS VSVDTFNSKN
   241  DVYVAIAQPS MENCMVLEWD HIEMNFRSYD NITGQSIVGC KAILIDDQVF VVVAQLFGGS
   301  HIYKYDESWT KFVKFQDIEV SRISKPNDIE LFQIDDETFF VIADSSKAGL STVYKWNSKG
   361  FYSYQSLHEW FRDTDAEFVD IDGKSHLILS SRSQVPIILQ WNKSSKKFVP HGDIPNMEDV
   421  LAVKSFRMQN TLYLSLTRFI GDSRVMRWNS KQFVEIQALP SRGAMTLQPF SFKDNHYLAL
   481  GSDYTFSQIY QWDKEKQLFK KFKEIYVQAP RSFTAVSTDR RDFFFASSFK GKTKIFEHII
   541  VDLSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 120 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 120 nTPM
fallopian tube: 13 nTPM
smooth muscle: 13 nTPM
tonsil: 7.9 nTPM
blood vessel: 7.6 nTPM
appendix: 7.1 nTPM

Single-cell type

smooth muscle cells: 34 nCPM
loop of henle epithelial cells: 22 nCPM
brain inhibitory neurons: 18 nCPM
retinal ganglion cells: 16 nCPM
vascular smooth muscle cells: 15 nCPM
macrophages: 13 nCPM

Immune cell

classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 27 nTPM
medulla oblongata: 25 nTPM
hypothalamus: 19 nTPM
pons: 14 nTPM
cerebral cortex: 12 nTPM
cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 1.63
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

inhibitory synapse assembly

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LGI2 as an antibody target. Whether an autoantibody or antibody against LGI2 could matter depends on whether native LGI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LGI2 is annotated as secreted, so native LGI2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LGI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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