Seroatlas · Human Serome Atlas

LETM2

LETM1 domain-containing protein LETM2, mitochondrial

Also known as: FLJ25409, LETM2_HUMAN, SLC55A2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2VYF4
Gene
LETM2
Ensembl
ENSG00000165046
Chromosome
8
Canonical length
491 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial calcium ion transmembrane transport and mitochondrion organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>Q2VYF4|LETM2
     1  MAFYSYNSVL AIARTRFPSH FVHPTCSSYS PSCAFLHLPD SHLNKTCMKN YESKKYSDPS
    61  QPGNTVLHPG TRLIQKLHTS TCWLQEVPGK PQLEQATKHP QVTSPQATKE TGMEIKEGKQ
   121  SYRQKIMDEL KYYYNGFYLL WIDAKVAARM VWRLLHGQVL TRRERRRLLR TCVDFFRLVP
   181  FMVFLIVPFM EFLLPVFLKL FPEMLPSTFE SESKKEEKQK KKMAVKLELA KFLQETMTEM
   241  ARRNRAKMGD ASTQLSSYVK QVQTGHKPST KEIVRFSKLF EDQLALEHLD RPQLVALCKL
   301  LELQTFGTNN LLRFQLLMKL KSIKADDEII AKEGVTALSV SELQAACRAR GMRSLGLTEE
   361  QLRQQLTEWQ DLHLKENVPP SLLLLSRTFY LIDVKPKPIE IPLSGEAPKT DILVELPTFT
   421  ESKENMVDLA PQLKGTKDED FIQPPPVTSS PITPSTPISL PKGPITSSEE PTLQAKSQMT
   481  AQNSKASSKG A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LETM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • testis: 22 nTPM
  • choroid plexus: 14 nTPM
  • bone marrow: 5 nTPM
  • retina: 3.9 nTPM
  • cerebellum: 3.8 nTPM
  • cerebral cortex: 2.6 nTPM

Single-cell type

  • epicardial cells: 175 nCPM
  • late primary spermatocytes: 132 nCPM
  • late spermatids: 75 nCPM
  • early spermatids: 50 nCPM
  • endometrial luminal cells: 42 nCPM
  • endometrial ciliated cells: 40 nCPM

Immune cell

  • neutrophil: 22 nTPM
  • non-classical monocyte: 5.2 nTPM
  • T-reg: 5.2 nTPM
  • classical monocyte: 4.1 nTPM
  • MAIT T-cell: 2 nTPM
  • naive B-cell: 1.8 nTPM

Brain region

  • cerebellum: 16 nTPM
  • white matter: 13 nTPM
  • cerebral cortex: 12 nTPM
  • basal ganglia: 12 nTPM
  • pons: 11 nTPM
  • midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0
gnomAD missense Z
-0.06
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LETM2 as an antibody target. Whether an autoantibody or antibody against LETM2 could matter depends on whether native LETM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LETM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LETM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LETM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...