Seroatlas · Human Serome Atlas

LENG9

Leukocyte receptor cluster member 9

Also known as: LENG9_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96B70
Gene: LENG9
Canonical length: 501 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for LENG9 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q96B70|LENG9
     1  MGSRPPCGAT SSARRACQFP APMAAAREPE LPQEAPATEP APPPACRFFL EGRCRFGARC
    61  RQPHPGAPAP PGREAQPEAG AKKPPLRTAA DVIQRIRWDP RLDPADFSVG YVDRFLGVRE
   121  EPFSAFCWDQ PLAALGPGVL AVPQHRVRFF RFHGRLVWDR ASRTDLVFGS GSAAGRGPTI
   181  LDAPNTEGAH GAEGAEWTLA GTGQEAQAAP KRGSTRPLCT GHQEPGVEEP GELEAAQERA
   241  LGTAADLGTL APRGRLAGVT EEALKPTAAT RTTLLGGKEA QALGVPGGSA ETTEAEWGPA
   301  AWPEDKRARL SVAAPCQPRP THFVALMVTE PGLQAEVTKA QEYLVHVAPH CANFLVPSQN
   361  LHLTLALLRL AGAGEEAAAI GALRRALLAP GLNAPPRLSF RKLVLLGPHV LCAPPSPTLE
   421  SMAQVLSQRL EAEGLSTLQS PGQLHPHLTV AKVPHGSQVH LPKLEFTLSQ EVGCQPLQTL
   481  WLCRIGRTGG PFQPLAEIRL E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LENG9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

pancreas: 28 nTPM
prostate: 10 nTPM
liver: 8.2 nTPM
esophagus: 7.9 nTPM
stomach: 7.8 nTPM
salivary gland: 7.4 nTPM

Single-cell type

microglia: 23 nCPM
oligodendrocytes: 11 nCPM
ependymal cells: 8.7 nCPM
oligodendrocyte progenitor cells: 8.4 nCPM
brain excitatory neurons: 6.8 nCPM
bergmann glia: 6.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 3.5 nTPM
white matter: 3.2 nTPM
medulla oblongata: 2.8 nTPM
cerebral cortex: 2.6 nTPM
basal ganglia: 2.4 nTPM
midbrain: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -2.07
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

Zinc finger, CCCH-type
Cyclic phosphodiesterase
A-kinase anchor protein 7-like, phosphoesterase domain
Zinc finger C-x8-C-x5-C-x3-H type (and similar)
AKAP7 2'5' RNA ligase-like domain
MJ1316 RNA cyclic group end recognition domain
Leukocyte receptor cluster member 9
MJ1316 RNA cyclic group end recognition domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LENG9 as an antibody target. Whether an autoantibody or antibody against LENG9 could matter depends on whether native LENG9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LENG9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LENG9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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