Seroatlas · Human Serome Atlas

LENG8

Leukocyte receptor cluster member 8

Also known as: KIAA1932, LENG8_HUMAN, MGC40108, pp13842

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PV6
Gene: LENG8
Ensembl: ENSG00000167615
Chromosome: 19
Canonical length: 800 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be part of protein-containing complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

800 residues, UniProt reviewed canonical sequence.

>Q96PV6|LENG8
     1  MAANVGDQRS TDWSSQYSMV AGAGRENGME TPMHENPEWE KARQALASIS KSGAAGGSAK
    61  SSSNGPVASA QYVSQAEASA LQQQQYYQWY QQYNYAYPYS YYYPMSMYQS YGSPSQYGMA
   121  GSYGSATPQQ PSAPQHQGTL NQPPVPGMDE SMSYQAPPQQ LPSAQPPQPS NPPHGAHTLN
   181  SGPQPGTAPA TQHSQAGPAT GQAYGPHTYT EPAKPKKGQQ LWNRMKPAPG TGGLKFNIQK
   241  RPFAVTTQSF GSNAEGQHSG FGPQPNPEKV QNHSGSSARG NLSGKPDDWP QDMKEYVERC
   301  FTACESEEDK DRTEKLLKEV LQARLQDGSA YTIDWSREPL PGLTREPVAE SPKKKRWEAA
   361  SSLHPPRGAG SATRGGGAPS QRGTPGAGGA GRARGNSFTK FGNRNVFMKD NSSSSSTDSR
   421  SRSSSRSPTR HFRRSDSHSD SDSSYSGNEC HPVGRRNPPP KGRGGRGAHM DRGRGRAQRG
   481  KRHDLAPTKR SRKKMAALEC EDPERELKKQ KRAARFQHGH SRRLRLEPLV LQMSSLESSG
   541  ADPDWQELQI VGTCPDITKH YLRLTCAPDP STVRPVAVLK KSLCMVKCHW KEKQDYAFAC
   601  EQMKSIRQDL TVQGIRTEFT VEVYETHARI ALEKGDHEEF NQCQTQLKSL YAENLPGNVG
   661  EFTAYRILYY IFTKNSGDIT TELAYLTREL KADPCVAHAL ALRTAWALGN YHRFFRLYCH
   721  APCMSGYLVD KFADRERKVA LKAMIKTFRP ALPVSYLQAE LAFEGEAACR AFLEPLGLAY
   781  TGPDNSSIDC RLSLAQLSAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LENG8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 510 nTPM

Expression across tissuesHPA

Tissue

pancreas: 510 nTPM
ovary: 399 nTPM
cerebellum: 394 nTPM
pituitary gland: 366 nTPM
spleen: 366 nTPM
thyroid gland: 356 nTPM

Single-cell type

podocytes: 208 nCPM
choroid plexus epithelial cells: 192 nCPM
ependymal cells: 116 nCPM
microglia: 116 nCPM
proximal tubule cells: 114 nCPM
renal collecting duct intercalated cells: 106 nCPM

Immune cell

neutrophil: 4.6 nTPM
basophil: 3.2 nTPM
plasmacytoid DC: 3.1 nTPM
naive B-cell: 2.5 nTPM
eosinophil: 1.4 nTPM
classical monocyte: 1 nTPM

Brain region

white matter: 190 nTPM
cerebral cortex: 182 nTPM
choroid plexus: 161 nTPM
hypothalamus: 161 nTPM
thalamus: 150 nTPM
cerebellum: 133 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 1.35
DepMap mean gene effect: -0.37
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LENG8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SNRPA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LENG8 as an antibody target. Whether an autoantibody or antibody against LENG8 could matter depends on whether native LENG8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LENG8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LENG8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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