Seroatlas · Human Serome Atlas

LENG1

Leukocyte receptor cluster member 1

Also known as: LENG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BZ8
Gene: LENG1
Ensembl: ENSG00000105617
Chromosome: 19
Canonical length: 264 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>Q96BZ8|LENG1
     1  MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL RKKARHQNSL
    61  PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYKEEK RQEKERQEKA LGILTYLGQS
   121  AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI KSRLDPLREM QKHLGKKRQH GGDEGSRSRK
   181  EKEGSEKQRP KEPPSLDQLR AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR
   241  RRYNSQFNPQ LARRPRQQDP HLTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LENG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 16 nTPM
testis: 16 nTPM
heart muscle: 13 nTPM
spinal cord: 13 nTPM
spleen: 13 nTPM
blood vessel: 12 nTPM

Single-cell type

late primary spermatocytes: 93 nCPM
oocytes: 88 nCPM
early spermatids: 64 nCPM
undifferentiated spermatogonia: 31 nCPM
ovarian stromal cells: 25 nCPM
syncytiotrophoblasts: 23 nCPM

Immune cell

eosinophil: 1.1 nTPM
memory CD4 T-cell: 0.9 nTPM
neutrophil: 0.8 nTPM
memory CD8 T-cell: 0.7 nTPM
NK-cell: 0.7 nTPM
classical monocyte: 0.6 nTPM

Brain region

pons: 2 nTPM
cerebellum: 1.3 nTPM
white matter: 1.3 nTPM
midbrain: 1 nTPM
basal ganglia: 0.8 nTPM
medulla oblongata: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -1.16
DepMap mean gene effect: -0.37
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

CBF1-interacting co-repressor CIR, N-terminal domain
N-terminal domain of CBF1 interacting co-repressor CIR
Leukocyte receptor cluster member 1-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LENG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LENG1 as an antibody target. Whether an autoantibody or antibody against LENG1 could matter depends on whether native LENG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LENG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LENG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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