LENEP
Lens epithelial cell protein LEP503
Also known as: LENEP_HUMAN, LEP503
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y5L5
- Gene
- LENEP
- Ensembl
- ENSG00000163352
- Chromosome
- 1
- Canonical length
- 61 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
OverviewNCBI Gene
The ocular lens is a tissue of epithelial origin and devoid of blood vessels and nerves. Cells of the lens epithelium are responsible for the growth and maintenance of the lens through mitosis, protein synthesis, and active transport of ions and metabolites across the lens capsule. Lens epithelial protein is expressed exclusively in lens epithelial cells and may play a role in cell differentiation. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
61 residues, UniProt reviewed canonical sequence.
>Q9Y5L5|LENEP
1 MQPRTQPLAQ TLPFFLGGAP RDTGLRVPVI KMGTGWEGFQ RTLKEVAYIL LCCWCIKELL
61 DLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LENEP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 0.3 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 0.3 nTPM
- kidney: 0.2 nTPM
- skin: 0.2 nTPM
- thyroid gland: 0.2 nTPM
- cervix: 0.1 nTPM
- endometrium: 0.1 nTPM
Single-cell type
- müller glia: 1 nCPM
- epididymal basal cells: 0.2 nCPM
- melanocytes: 0.2 nCPM
- ocular epithelial cells: 0.2 nCPM
- rod photoreceptor cells: 0.2 nCPM
- early primary spermatocytes: 0.1 nCPM
Immune cell
- myeloid DC: 0.1 nTPM
- naive CD8 T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebral cortex: 3.5 nTPM
- cerebellum: 3.4 nTPM
- white matter: 3.2 nTPM
- thalamus: 2.8 nTPM
- medulla oblongata: 2.6 nTPM
- pons: 2.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.93
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.4
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- Lens epithelial cell protein LEP503
- Lens epithelial cell protein LEP503
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LENEP as an antibody target. Whether an autoantibody or antibody against LENEP could matter depends on whether native LENEP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LENEP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LENEP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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