Seroatlas · Human Serome Atlas

LELP1

Late cornified envelope-like proline-rich protein 1

Also known as: LELP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T871
Gene
LELP1
Ensembl
ENSG00000203784
Chromosome
1
Canonical length
98 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for LELP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

98 residues, UniProt reviewed canonical sequence.

>Q5T871|LELP1
     1  MSSDDKSKSN DPKTEPKNCD PKCEQKCESK CQPSCLKKLL QRCFEKCPWE KCPAPPKCLP
    61  CPSQSPSSCP PQPCTKPCPP KCPSSCPHAC PPPCPPPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LELP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
1,035 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1,035 nTPM
  • prostate: 0.7 nTPM
  • breast: 0.6 nTPM
  • colon: 0.3 nTPM
  • liver: 0.3 nTPM
  • skeletal muscle: 0.3 nTPM

Single-cell type

  • late spermatids: 39,637 nCPM
  • early spermatids: 4,126 nCPM
  • late primary spermatocytes: 731 nCPM
  • leydig cells: 44 nCPM
  • sertoli cells: 36 nCPM
  • early primary spermatocytes: 21 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0.43
gnomAD missense Z
-0.29
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Late cornified envelope-like proline-rich protein 1
  • Late cornified envelope-like proline-rich protein 1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LELP1 as an antibody target. Whether an autoantibody or antibody against LELP1 could matter depends on whether native LELP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LELP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LELP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LELP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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