LEG1
Protein LEG1 homolog
Also known as: C6orf58, LEG1H_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P5S2
- Gene
- LEG1
- Ensembl
- ENSG00000184530
- Chromosome
- 6
- Canonical length
- 330 aa
- Protein class
- Predicted secreted proteins
- Subcellular location
- Nucleoplasm,Vesicles,Cytosol
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
330 residues, UniProt reviewed canonical sequence.
>Q6P5S2|LEG1
1 MAFLPSWVCV LVGSFSASLA GTSNLSETEP PLWKESPGQL SDYRVENSMY IINPWVYLER
61 MGMYKIILNQ TARYFAKFAP DNEQNILWGL PLQYGWQYRT GRLADPTRRT NCGYESGDHM
121 CISVDSWWAD LNYFLSSLPF LAAVDSGVMG ISSDQVRLLP PPKNERKFCY DVSSCRSSFP
181 ETMNKWNTFY QYLQSPFSKF DDLLKYLWAA HTSTLADNIK SFEDRYDYYS KAEAHFERSW
241 VLAVDHLAAV LFPTTLIRSY KFQKGMPPRI LLNTDVAPFI SDFTAFQNVV LVLLNMLDNV
301 DKSIGYLCTE KSNVYRDHSE SSSRSYGNNSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LEG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 2,319 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 2,319 nTPM
- duodenum: 578 nTPM
- stomach: 254 nTPM
- esophagus: 15 nTPM
- lung: 1 nTPM
- pancreas: 0.9 nTPM
Single-cell type
- mucous neck cells: 426 nCPM
- submucosal glandular cells: 159 nCPM
- gastric chief cells: 83 nCPM
- neuroendocrine cells: 25 nCPM
- late primary spermatocytes: 22 nCPM
- early spermatids: 12 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 1.3 nTPM
- white matter: 1.2 nTPM
- choroid plexus: 0.5 nTPM
- basal ganglia: 0.3 nTPM
- cerebellum: 0.2 nTPM
- amygdala: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.31
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Leg1
- Leg1
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LEG1 as an antibody target. Whether an autoantibody or antibody against LEG1 could matter depends on whether native LEG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LEG1 is annotated as secreted, so native LEG1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label LEG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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