Seroatlas · Human Serome Atlas

LECT2

Leukocyte cell-derived chemotaxin-2

Also known as: chm-II, chm2, LECT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14960
Gene: LECT2
Ensembl: ENSG00000145826
Chromosome: 5
Canonical length: 151 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Vesicles,Cytosol
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>O14960|LECT2
     1  MFSTKALLLA GLISTALAGP WANICAGKSS NEIRTCDRHG CGQYSAQRSQ RPHQGVDILC
    61  SAGSTVYAPF TGMIVGQEKP YQNKNAINNG VRISGRGFCV KMFYIKPIKY KGPIKKGEKL
   121  GTLLPLQKVY PGIQSHVHIE NCDSSDPTAY L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LECT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 445 nTPM

Expression across tissuesHPA

Tissue

liver: 445 nTPM
testis: 8.3 nTPM
retina: 2.3 nTPM
bone marrow: 2 nTPM
skeletal muscle: 1.9 nTPM
skin: 1.1 nTPM

Single-cell type

early spermatids: 152 nCPM
hepatocytes: 107 nCPM
late primary spermatocytes: 104 nCPM
late spermatids: 64 nCPM
retinal horizontal cells: 28 nCPM
retinal ganglion cells: 12 nCPM

Immune cell

basophil: 0.6 nTPM
memory B-cell: 0.2 nTPM
eosinophil: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

cerebellum: 27 nTPM
cerebral cortex: 20 nTPM
white matter: 17 nTPM
basal ganglia: 17 nTPM
hypothalamus: 16 nTPM
amygdala: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Leukocyte cell-derived chemotaxin 2
Duplicated hybrid motif
M23ase, beta-sheet core domain
Leukocyte cell-derived chemotaxin 2, chordata
Peptidase family M23

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LECT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LECT2 as an antibody target. Whether an autoantibody or antibody against LECT2 could matter depends on whether native LECT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LECT2 is annotated as secreted, so native LECT2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LECT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...