Seroatlas · Human Serome Atlas

LEAP2

Liver-expressed antimicrobial peptide 2

Also known as: LEAP-2, LEAP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969E1
Gene
LEAP2
Ensembl
ENSG00000164406
Chromosome
5
Canonical length
77 aa
Protein class
Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

77 residues, UniProt reviewed canonical sequence.

>Q969E1|LEAP2
     1  MWHLKLCAVL MIFLLLLGQI DGSPIPEVSS AKRRPRRMTP FWRGVSLRPI GASCRDDSEC
    61  ITRLCRKRRC SLSVAQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LEAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
496 nTPM

Expression across tissuesHPA

Tissue

  • liver: 496 nTPM
  • small intestine: 22 nTPM
  • duodenum: 12 nTPM
  • kidney: 11 nTPM
  • urinary bladder: 7.4 nTPM
  • gallbladder: 4.2 nTPM

Single-cell type

  • hepatocytes: 1,982 nCPM
  • enterocytes: 265 nCPM
  • urothelial cells: 126 nCPM
  • cholangiocytes: 73 nCPM
  • parietal cells: 42 nCPM
  • epididymal efferent duct absorptive cells: 39 nCPM

Immune cell

  • neutrophil: 1.6 nTPM
  • basophil: 1.2 nTPM
  • memory B-cell: 1 nTPM
  • naive CD4 T-cell: 1 nTPM
  • NK-cell: 1 nTPM
  • T-reg: 1 nTPM

Brain region

  • cerebellum: 6 nTPM
  • white matter: 4.8 nTPM
  • cerebral cortex: 3.7 nTPM
  • pons: 3.7 nTPM
  • basal ganglia: 3.3 nTPM
  • hippocampal formation: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.87
gnomAD pLI
0
gnomAD missense Z
0.01
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Liver-expressed antimicrobial peptide 2
  • Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LEAP2 as an antibody target. Whether an autoantibody or antibody against LEAP2 could matter depends on whether native LEAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LEAP2 is annotated as secreted, so native LEAP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LEAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LEAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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