Seroatlas · Human Serome Atlas

LDLRAD2

Low-density lipoprotein receptor class A domain-containing protein 2

Also known as: LRAD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SZI1
Gene: LDLRAD2
Ensembl: ENSG00000187942
Chromosome: 1
Canonical length: 272 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>Q5SZI1|LDLRAD2
     1  MEACCLLQLP QRLLLLGAAA LTATALETAD LAELCGQTWQ GDGLLLRSHA ASRRFYFVAP
    61  DTDCGLWVQA AAPGDRIRFQ FRFFLVYSLT PAPPALNTSS PAPADPCAPG SYLQFYEGPP
   121  GAPRPLGSPL CGLNIPVPVA SSGPFLGLRL VTRGRQPRVD FVGEVTSFRL GPCGAYFRCQ
   181  NGRCIPSSLV CDPWGMDNCG DGSDQGSWSP ADCRGPSPVP SQTGSTDAHT SRSLTPSPAL
   241  GSAGSLWIAA ERSSPAGRDP TRQDAALEGS TE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LDLRAD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 7.6 nTPM
salivary gland: 7.2 nTPM
colon: 4.5 nTPM
blood vessel: 3.7 nTPM
prostate: 3.7 nTPM
urinary bladder: 3.7 nTPM

Single-cell type

cardiomyocytes: 108 nCPM
epicardial cells: 57 nCPM
vascular endothelial cells: 45 nCPM
adipocytes: 35 nCPM
fibroblasts: 29 nCPM
ependymal cells: 25 nCPM

Immune cell

plasmacytoid DC: 0.5 nTPM
basophil: 0.4 nTPM
memory B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

midbrain: 7 nTPM
medulla oblongata: 5.3 nTPM
spinal cord: 3.8 nTPM
pons: 3.7 nTPM
hypothalamus: 3 nTPM
hippocampal formation: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LDLRAD2 as an antibody target. Whether an autoantibody or antibody against LDLRAD2 could matter depends on whether native LDLRAD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LDLRAD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LDLRAD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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