Seroatlas · Human Serome Atlas

LDAH

Lipid droplet-associated hydrolase

Also known as: C2orf43, FLJ21820, LDAH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6V9
Gene: LDAH
Ensembl: ENSG00000118961
Chromosome: 2
Canonical length: 325 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable sterol ester esterase activity. Involved in cholesterol homeostasis and intracellular triglyceride homeostasis. Acts upstream of with a positive effect on lipid droplet fusion. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q9H6V9|LDAH
     1  MDSELKEEIP VHEEFILCGG AETQVLKCGP WTDLFHDQSV KRPKLLIFII PGNPGFSAFY
    61  VPFAKALYSL TNRRFPVWTI SHAGHALAPK DKKILTTSED SNAQEIKDIY GLNGQIEHKL
   121  AFLRTHVPKD MKLVLIGHSI GSYFTLQMLK RVPELPVIRA FLLFPTIERM SESPNGRIAT
   181  PLLCWFRYVL YVTGYLLLKP CPETIKSLLI RRGLQVMNLE NEFSPLNILE PFCLANAAYL
   241  GGQEMMEVVK RDDETIKEHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH
   301  AFITHFNQEM ADMIADSLKD DLSKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LDAH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

kidney: 16 nTPM
tonsil: 13 nTPM
adrenal gland: 11 nTPM
liver: 11 nTPM
rectum: 11 nTPM
thymus: 11 nTPM

Single-cell type

adrenal cortex cells: 154 nCPM
proximal tubule cells: 126 nCPM
podocytes: 110 nCPM
sertoli cells: 107 nCPM
gonadotrophs: 106 nCPM
distal convoluted tubule cells: 99 nCPM

Immune cell

memory B-cell: 7.8 nTPM
gdT-cell: 6.6 nTPM
memory CD4 T-cell: 6.5 nTPM
T-reg: 6.1 nTPM
naive CD4 T-cell: 5.9 nTPM
naive CD8 T-cell: 5.9 nTPM

Brain region

white matter: 18 nTPM
choroid plexus: 16 nTPM
basal ganglia: 16 nTPM
hypothalamus: 15 nTPM
medulla oblongata: 14 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

sterol ester esterase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Alpha/Beta hydrolase fold
Lipid droplet-associated hydrolase
Lipid-droplet associated hydrolase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LDAH as an antibody target. Whether an autoantibody or antibody against LDAH could matter depends on whether native LDAH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LDAH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LDAH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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