Seroatlas · Human Serome Atlas

LCORL

Ligand-dependent nuclear receptor corepressor-like protein

Also known as: FLJ30696, LCORL_HUMAN, MLR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N3X6
Gene
LCORL
Ensembl
ENSG00000178177
Chromosome
4
Canonical length
602 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

602 residues, UniProt reviewed canonical sequence.

>Q8N3X6|LCORL
     1  MDKGRERMAA AAAAAAAAAA AAQCRSPRCA AERRGFRREL DSWRHRLMHC VGFESILEGL
    61  YGPRLRRDLS LFEDCEPEEL TDWSMDEKCS FCNLQREAVS DCIPSLDSSQ STPTEELSSQ
   121  GQSNTDKIEC QAENYLNALF RKKDLPQNCD PNIPLVAQEL MKKMIRQFAI EYISKSGKTQ
   181  ENRNGSIGPS IVCKSIQMNQ AENSLQEEQE GPLDLTVNRM QEQNTQQGDG VLDLSTKKTS
   241  IKSEESSICD PSSENSVAGR LHRNREDYVE RSAEFADGLL SKALKDIQSG ALDINKAGIL
   301  YGIPQKTLLL HLEALPAGKP ASFKNKTRDF HDSYSYKDSK ETCAVLQKVA LWARAQAERT
   361  EKSKLNLLET SEIKFPTAST YLHQLTLQKM VTQFKEKNES LQYETSNPTV QLKIPQLRVS
   421  SVSKSQPDGS GLLDVMYQVS KTSSVLEGSA LQKLKNILPK QNKIECSGPV THSSVDSYFL
   481  HGDLSPLCLN SKNGTVDGTS ENTEDGLDRK DSKQPRKKRG RYRQYDHEIM EEAIAMVMSG
   541  KMSVSKAQGI YGVPHSTLEY KVKERSGTLK TPPKKKLRLP DTGLYNMTDS GTGSCKNSSK
   601  PV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCORL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
6.6 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 6.6 nTPM
  • retina: 6.1 nTPM
  • duodenum: 5.5 nTPM
  • testis: 5.5 nTPM
  • skin: 4.5 nTPM
  • parathyroid gland: 4.3 nTPM

Single-cell type

  • thyrotrophs: 340 nCPM
  • neuroendocrine cells: 288 nCPM
  • somatotrophs: 260 nCPM
  • cone photoreceptor cells: 238 nCPM
  • oligodendrocytes: 236 nCPM
  • adrenal medulla cells: 234 nCPM

Immune cell

  • basophil: 7.7 nTPM
  • intermediate monocyte: 3.5 nTPM
  • naive B-cell: 3.5 nTPM
  • classical monocyte: 3.3 nTPM
  • eosinophil: 3.3 nTPM
  • non-classical monocyte: 3.1 nTPM

Brain region

  • hypothalamus: 20 nTPM
  • cerebellum: 19 nTPM
  • midbrain: 16 nTPM
  • white matter: 16 nTPM
  • medulla oblongata: 13 nTPM
  • basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.92
gnomAD missense Z
1.66
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LCORL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCORL as an antibody target. Whether an autoantibody or antibody against LCORL could matter depends on whether native LCORL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCORL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LCORL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LCORL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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