LCNL1
Lipocalin-like 1 protein
Also known as: FLJ45224, LCNL1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZST4
- Gene
- LCNL1
- Ensembl
- ENSG00000214402
- Chromosome
- 9
- Canonical length
- 164 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable small molecule binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
164 residues, UniProt reviewed canonical sequence.
>Q6ZST4|LCNL1
1 MVGVVSDDQD FLDSKDTMKM AVVLVTPLGN GDLALKFGYP TPHGGCQKMD TTFTEGAVPG
61 QFSNPAMALS DIRVAFSDYQ HFALLYLEMR KGGLRNQWLQ LYGGRAAGRR PRHPRFGSGM
121 SPLCLHQPFL HAEGGTAGSW CLWPRVPAPP CPSLPLFAPP APSLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LCNL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 2.2 nTPM
Expression across tissuesHPA
Tissue
- midbrain: 2.2 nTPM
- spinal cord: 1.8 nTPM
- cerebral cortex: 1.6 nTPM
- testis: 1.6 nTPM
- hippocampal formation: 1.4 nTPM
- amygdala: 1.3 nTPM
Single-cell type
- peritubular myoid cells: 160 nCPM
- astrocytes: 157 nCPM
- leydig cells: 87 nCPM
- retinal pigment epithelial cells: 60 nCPM
- bergmann glia: 54 nCPM
- podocytes: 47 nCPM
Immune cell
- plasmacytoid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 0.9 nTPM
- thalamus: 0.9 nTPM
- medulla oblongata: 0.8 nTPM
- pons: 0.8 nTPM
- white matter: 0.8 nTPM
- hypothalamus: 0.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.88
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.74
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LCNL1 as an antibody target. Whether an autoantibody or antibody against LCNL1 could matter depends on whether native LCNL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LCNL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LCNL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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