Seroatlas · Human Serome Atlas

LCN9

Epididymal-specific lipocalin-9

Also known as: LCN9_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WX39
Gene
LCN9
Canonical length
176 aa
Protein class
Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for LCN9 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q8WX39|LCN9
     1  MALLLLSLGL SLIAAQEFDP HTVMQRNYNV ARVSGVWYSI FMASDDLNRI KENGDLRVFV
    61  RNIEHLKNGS LIFDFEYMVQ GECVAVVVVC EKTEKNGEYS INYEGQNTVA VSETDYRLFI
   121  TFHLQNFRNG TETHTLALYE TCEKYGLGSQ NIIDLTNKDP CYSKHYRSPP RPPMRW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCN9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • epididymal principal cells: 24 nCPM
  • epididymal clear cells: 2 nCPM
  • epididymal efferent duct ciliated cells: 0.4 nCPM
  • epididymal basal cells: 0.3 nCPM
  • epididymal efferent duct absorptive cells: 0.2 nCPM
  • fallopian tube ciliated cells: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • pons: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
-0.1
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCN9 as an antibody target. Whether an autoantibody or antibody against LCN9 could matter depends on whether native LCN9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCN9 is annotated as secreted, so native LCN9 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LCN9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LCN9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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