Seroatlas · Human Serome Atlas

LCN8

Epididymal-specific lipocalin-8

Also known as: LCN5, LCN8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6JVE9
Gene: LCN8
Ensembl: ENSG00000204001
Chromosome: 9
Canonical length: 175 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Members of the lipocalin family, such as LCN8, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>Q6JVE9|LCN8
     1  MPGAAEALPT VTVTLVAGAV PPASGALTAH CIGGFWREVG VASDQSLVLT APKRVEGLFL
    61  TLSGSNLTVK VAYNSSGSCE IEKIVGSEID STGKFAFPGH REIHVLDTDY EGYAILRVSL
   121  MWRGRNFRVL KYFTRSLEDK DRLGFWKFRE LTADTGLYLA ARPGRCAELL KEELI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCN8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

epididymis: 79 nTPM
cerebellum: 1.8 nTPM
thyroid gland: 0.5 nTPM
lymph node: 0.4 nTPM
skeletal muscle: 0.4 nTPM
spleen: 0.3 nTPM

Single-cell type

epididymal principal cells: 2,176 nCPM
epididymal efferent duct absorptive cells: 435 nCPM
epididymal efferent duct ciliated cells: 60 nCPM
epididymal basal cells: 19 nCPM
epididymal clear cells: 12 nCPM
mast cells: 3.7 nCPM

Immune cell

naive B-cell: 8.2 nTPM
memory B-cell: 4.1 nTPM
plasmacytoid DC: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 1.8 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCN8 as an antibody target. Whether an autoantibody or antibody against LCN8 could matter depends on whether native LCN8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCN8 is annotated as secreted, so native LCN8 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LCN8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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