Seroatlas · Human Serome Atlas

LCN6

Epididymal-specific lipocalin-6

Also known as: LCN6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62502
Gene: LCN6
Ensembl: ENSG00000267206
Chromosome: 9
Canonical length: 163 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to enable small molecule binding activity. Predicted to be involved in single fertilization. Predicted to act upstream of or within several processes, including acrosome reaction; calcium ion homeostasis; and response to calcium ion. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>P62502|LCN6
     1  MGGLLLAAFL ALVSVPRAQA VWLGRLDPEQ LLGPWYVLAV ASREKGFAME KDMKNVVGVV
    61  VTLTPENNLR TLSSQHGLGG CDQSVMDLIK RNSGWVFENP SIGVLELWVL ATNFRDYAII
   121  FTQLEFGDEP FNTVELYSLT ETASQEAMGL FTKWSRSLGF LSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 1,493 nTPM

Expression across tissuesHPA

Tissue

epididymis: 1,493 nTPM
heart muscle: 23 nTPM
endometrium: 19 nTPM
cervix: 11 nTPM
fallopian tube: 10 nTPM
adipose tissue: 9.5 nTPM

Single-cell type

epididymal principal cells: 4,552 nCPM
epididymal clear cells: 65 nCPM
vascular endothelial cells: 60 nCPM
epididymal basal cells: 58 nCPM
epididymal efferent duct absorptive cells: 29 nCPM
mast cells: 22 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 2.4 nTPM
amygdala: 1.5 nTPM
cerebral cortex: 1.3 nTPM
midbrain: 1.3 nTPM
medulla oblongata: 1.1 nTPM
pons: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: -0.24
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

small molecule binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCN6 as an antibody target. Whether an autoantibody or antibody against LCN6 could matter depends on whether native LCN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCN6 is annotated as secreted, so native LCN6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LCN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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