Seroatlas · Human Serome Atlas

LCN15

Lipocalin-15

Also known as: LCN15_HUMAN, PRO6093, UNQ2541

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWW0
Gene: LCN15
Ensembl: ENSG00000177984
Chromosome: 9
Canonical length: 184 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable small molecule binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q6UWW0|LCN15
     1  MMSFLLGAIL TLLWAPTAQA EVLLQPDFNA EKFSGLWYVV SMASDCRVFL GKKDHLSMST
    61  RAIRPTEEGG LHVHMEFPGA DGCNQVDAEY LKVGSEGHFR VPALGYLDVR IVDTDYSSFA
   121  VLYIYKELEG ALSTMVQLYS RTQDVSPQAL KSFQDFYPTL GLPKDMMVML PQSDACNPES
   181  KEAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCN15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

duodenum: 11 nTPM
small intestine: 3.5 nTPM
seminal vesicle: 3.1 nTPM
colon: 2.8 nTPM
cerebral cortex: 2.2 nTPM
rectum: 1.8 nTPM

Single-cell type

neuroendocrine cells: 1,256 nCPM
epididymal principal cells: 48 nCPM
colonocytes: 13 nCPM
late spermatids: 4.3 nCPM
epididymal efferent duct absorptive cells: 3.7 nCPM
epididymal efferent duct ciliated cells: 2.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.9 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

small molecule binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCN15 as an antibody target. Whether an autoantibody or antibody against LCN15 could matter depends on whether native LCN15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCN15 is annotated as secreted, so native LCN15 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LCN15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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