Seroatlas · Human Serome Atlas

LCN10

Epididymal-specific lipocalin-10

Also known as: LCN10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6JVE6
Gene: LCN10
Ensembl: ENSG00000187922
Chromosome: 9
Canonical length: 187 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]

Canonical amino-acid sequenceUniProt

187 residues, UniProt reviewed canonical sequence.

>Q6JVE6|LCN10
     1  MRQGLLVLAL VLVLVLVLAA GSQVQEWYPR ESHALNWNKF SGFWYILATA TDAQGFLPAR
    61  DKRKLGASVV KVNKVGQLRV LLAFRRGQGC GRAQPRHPGT SGHLWASLSV KGVKAFHVLS
   121  TDYSYGLVYL RLGRATQNYK NLLLFHRQNV SSFQSLKEFM DACDILGLSK AAVILPKDAS
   181  RTHTILP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCN10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

epididymis: 31 nTPM
heart muscle: 16 nTPM
endometrium: 14 nTPM
cervix: 11 nTPM
fallopian tube: 10 nTPM
adipose tissue: 7.2 nTPM

Single-cell type

b-cells: 0.5 nCPM
vascular endothelial cells: 0.2 nCPM
astrocytes: 0.1 nCPM
cardiomyocytes: 0.1 nCPM
choroid plexus epithelial cells: 0.1 nCPM
epididymal efferent duct absorptive cells: 0.1 nCPM

Immune cell

memory B-cell: 6.5 nTPM
naive B-cell: 6.4 nTPM
T-reg: 0.3 nTPM
total PBMC: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
NK-cell: 0.2 nTPM

Brain region

thalamus: 0.9 nTPM
amygdala: 0.5 nTPM
cerebral cortex: 0.5 nTPM
medulla oblongata: 0.5 nTPM
basal ganglia: 0.4 nTPM
pons: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

small molecule binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCN10 as an antibody target. Whether an autoantibody or antibody against LCN10 could matter depends on whether native LCN10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCN10 is annotated as secreted, so native LCN10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LCN10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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