Seroatlas · Human Serome Atlas

LCE7A

Late cornified envelope protein 7A

Also known as: LCE7A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DV60
Gene
LCE7A
Ensembl
ENSG00000285946
Chromosome
1
Canonical length
95 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>P0DV60|LCE7A
     1  MSYQKHQQKW QLPAKCLPKY PSKWTPQAPA SCPAPCPPPA PSCCVSSCCI SGFGGHCSLV
    61  SLRFPRFYLR QPQHSDCCEH ESSRCSTCYS SGDCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCE7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
2 nTPM

Expression across tissuesHPA

Tissue

  • skin: 2 nTPM
  • breast: 0.3 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • urothelial cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCE7A as an antibody target. Whether an autoantibody or antibody against LCE7A could matter depends on whether native LCE7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCE7A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LCE7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LCE7A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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