LCE2B
Late cornified envelope protein 2B
Also known as: LCE2B_HUMAN, LEP10, SPRL1B, XP5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O14633
- Gene
- LCE2B
- Ensembl
- ENSG00000159455
- Chromosome
- 1
- Canonical length
- 110 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
This gene is one of the at least 20 genes expressed during epidermal differentiation and located on chromosomal band 1q21. This gene is involved in epidermal differentiation, and it is expressed at high levels in normal and psoriatic skin, but not in cultured keratinocytes or in any other tested cell types or tissues. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
110 residues, UniProt reviewed canonical sequence.
>O14633|LCE2B
1 MSCQQNQQQC QPPPKCPPKC TPKCPPKCPP KCLPQCPAPC SPAVSSCCGP ISGGCCGPSS
61 GGCCNSGAGG CCLSHHRPRL FHRRRHQSPD CCESEPSGGS GCCHSSGGCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LCE2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.75
- Highest tissue expression
- 717 nTPM
Expression across tissuesHPA
Tissue
- skin: 717 nTPM
- breast: 39 nTPM
- skeletal muscle: 5.7 nTPM
- cervix: 1 nTPM
- tonsil: 0.9 nTPM
- salivary gland: 0.6 nTPM
Single-cell type
- vascular smooth muscle cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.88
- gnomAD pLI
- 0.1
- gnomAD missense Z
- -1.84
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LCE2B as an antibody target. Whether an autoantibody or antibody against LCE2B could matter depends on whether native LCE2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LCE2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LCE2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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