LCE1F
Late cornified envelope protein 1F
Also known as: LCE1F_HUMAN, LEP6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T754
- Gene
- LCE1F
- Ensembl
- ENSG00000240386
- Chromosome
- 1
- Canonical length
- 118 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
118 residues, UniProt reviewed canonical sequence.
>Q5T754|LCE1F
1 MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG CCGSSSGGCC
61 SSGGGGCCSS GGGGCCLSHH RRRRSHRHRP QSSDCCSQPS AGSSCCGGGS GQHSGGCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LCE1F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.74
- Highest tissue expression
- 155 nTPM
Expression across tissuesHPA
Tissue
- skin: 155 nTPM
- breast: 9.2 nTPM
- cervix: 1.6 nTPM
- skeletal muscle: 1.1 nTPM
- salivary gland: 0.4 nTPM
- thymus: 0.2 nTPM
Single-cell type
- esophageal apical cells: 0.3 nCPM
- esophageal basal cells: 0.1 nCPM
- undifferentiated spermatogonia: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about LCE1F.
Disease | ImmuneIEDB
Conditions an epitope on LCE1F was assayed in.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.16
- DepMap mean gene effect
- -0.88
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LCE1F as an antibody target. Whether an autoantibody or antibody against LCE1F could matter depends on whether native LCE1F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LCE1F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LCE1F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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