Seroatlas · Human Serome Atlas

LCA5L

Lebercilin-like protein

Also known as: C21orf13, LCA5L_HUMAN, MGC33295

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95447
Gene
LCA5L
Ensembl
ENSG00000157578
Chromosome
21
Canonical length
670 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear speckles,Cytosol,Flagellar centriole,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to be involved in intraciliary transport. Predicted to be active in axoneme. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

670 residues, UniProt reviewed canonical sequence.

>O95447|LCA5L
     1  MSLADLTKTN IDEHFFGVAL ENNRRSAACK RSPGTGDFSR NSNASNKSVD YSRSQCSCGS
    61  LSSQYDYSED FLCDCSEKAI NRNYLKQPVV KEKEKKKYNV SKISQSKGQK EISVEKKHTW
   121  NASLFNSQIH MIAQRRDAMA HRILSARLHK IKGLKNELAD MHHKLEAILT ENQFLKQLQL
   181  RHLKAIGKYE NSQNNLPQIM AKHQNEVKNL RQLLRKSQEK ERTLSRKLRE TDSQLLKTKD
   241  ILQALQKLSE DKNLAEREEL THKLSIITTK MDANDKKIQS LEKQLRLNCR AFSRQLAIET
   301  RKTLAAQTAT KTLQVEVKHL QQKLKEKDRE LEIKNIYSHR ILKNLHDTED YPKVSSTKSV
   361  QADRKILPFT SMRHQGTQKS DVPPLTTKGK KATGNIDHKE KSTEINHEIP HCVNKLPKQE
   421  DSKRKYEDLS GEEKHLEVQI LLENTGRQKD KKEDQEKKNI FVKEEQELPP KIIEVIHPER
   481  ESNQEDVLVR EKFKRSMQRN GVDDTLGKGT APYTKGPLRQ RRHYSFTEAT ENLHHGLPAS
   541  GGPANAGNMR YSHSTGKHLS NREEMELEHS DSGYEPSFGK SSRIKVKDTT FRDKKSSLME
   601  ELFGSGYVLK TDQSSPGVAK GSEEPLQSKE SHPLPPSQAS TSHAFGDSKV TVVNSIKPSS
   661  PTEGKRKIII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LCA5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
103 nTPM

Expression across tissuesHPA

Tissue

  • testis: 103 nTPM
  • retina: 10 nTPM
  • epididymis: 7.3 nTPM
  • fallopian tube: 6.8 nTPM
  • thyroid gland: 4.1 nTPM
  • choroid plexus: 2.3 nTPM

Single-cell type

  • late primary spermatocytes: 1,581 nCPM
  • early spermatids: 1,232 nCPM
  • late spermatids: 685 nCPM
  • respiratory ciliated cells: 135 nCPM
  • early primary spermatocytes: 128 nCPM
  • ependymal cells: 124 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 10 nTPM
  • midbrain: 8.5 nTPM
  • medulla oblongata: 7.7 nTPM
  • spinal cord: 7.5 nTPM
  • cerebellum: 5.9 nTPM
  • cerebral cortex: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0
gnomAD missense Z
0.51
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LCA5L as an antibody target. Whether an autoantibody or antibody against LCA5L could matter depends on whether native LCA5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LCA5L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LCA5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LCA5L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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