Seroatlas · Human Serome Atlas

LBX2

Transcription factor LBX2

Also known as: LBX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6XYB7
Gene: LBX2
Ensembl: ENSG00000179528
Chromosome: 2
Canonical length: 198 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Midbody

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including positive regulation of convergent extension involved in gastrulation; positive regulation of non-canonical Wnt signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q6XYB7|LBX2
     1  MNSGREPRTP RTLLSIADIL APRMVPRAPS APQLPESGPG PTSPLCALEE LTSKTFRGLD
    61  ARALQPSEGR AGPDALGPGP FGRKRRKSRT AFTAQQVLEL ERRFVFQKYL APSERDGLAT
   121  RLGLANAQVV TWFQNRRAKL KRDVEEMRAD VASLRALSPE VLCSLALPEG APDPGLCLGP
   181  AGPDSRPHLS DEEIQVDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LBX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

liver: 9.1 nTPM
duodenum: 5 nTPM
small intestine: 4.5 nTPM
stomach: 3 nTPM
adipose tissue: 1.2 nTPM
kidney: 1.2 nTPM

Single-cell type

megakaryocytes: 12 nCPM
gastric progenitor cells: 7.7 nCPM
hofbauer cells: 6.9 nCPM
gastric chief cells: 6.6 nCPM
hepatocytes: 5.8 nCPM
enterocytes: 5.6 nCPM

Immune cell

non-classical monocyte: 2.2 nTPM
classical monocyte: 1.5 nTPM
NK-cell: 1.1 nTPM
intermediate monocyte: 0.8 nTPM
myeloid DC: 0.8 nTPM
total PBMC: 0.7 nTPM

Brain region

white matter: 4.3 nTPM
cerebellum: 3.9 nTPM
medulla oblongata: 3.1 nTPM
pons: 3.1 nTPM
cerebral cortex: 2.8 nTPM
thalamus: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0.01
gnomAD missense Z: -0.16
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LBX2 as an antibody target. Whether an autoantibody or antibody against LBX2 could matter depends on whether native LBX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LBX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LBX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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