LBHD2
LBH domain-containing protein 2
Also known as: LBHD2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0U1RRK4
- Gene
- LBHD2
- Ensembl
- ENSG00000283071
- Chromosome
- 14
- Canonical length
- 108 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for LBHD2 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
108 residues, UniProt reviewed canonical sequence.
>A0A0U1RRK4|LBHD2
1 MSTPRPAPPQ PGAAEGAGGP EGKAVAGAWE KGPRLGQRLP SIVVEPSEAD PVESGELRWP
61 LESAQRGPSQ SRAAAAPSPS LPGEPGKAAD NAGSECACSE DPAAPARGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LBHD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.72
- Highest tissue expression
- 9.7 nTPM
Expression across tissuesHPA
Tissue
- hypothalamus: 9.7 nTPM
- hippocampal formation: 7.6 nTPM
- amygdala: 4.8 nTPM
- cerebral cortex: 3.2 nTPM
- testis: 3 nTPM
- midbrain: 2.1 nTPM
Single-cell type
- late spermatids: 8.5 nCPM
- decidual stromal cells: 5.5 nCPM
- oocytes: 4.6 nCPM
- undifferentiated spermatogonia: 4.2 nCPM
- other brain neurons: 3.1 nCPM
- sertoli cells: 2.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 22 nTPM
- pons: 7.7 nTPM
- basal ganglia: 7.3 nTPM
- hippocampal formation: 5.9 nTPM
- medulla oblongata: 4.5 nTPM
- thalamus: 3.1 nTPM
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LBHD2 as an antibody target. Whether an autoantibody or antibody against LBHD2 could matter depends on whether native LBHD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LBHD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LBHD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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