Seroatlas · Human Serome Atlas

LBHD1

LBH domain-containing protein 1

Also known as: C11orf48, LBHD1_HUMAN, MGC2477

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BQE6
Gene
LBHD1
Ensembl
ENSG00000162194
Chromosome
11
Canonical length
289 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene shares three exons in common with another gene, chromosome 11 open reading frame 98 (GeneID:102288414), but the encoded protein uses a reading frame that is different from that of the chromosome 11 open reading frame 98 gene. [provided by RefSeq, Nov 2017]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>Q9BQE6|LBHD1
     1  MALVPGRSKE DGLWTRNSPG SSQHPESPRL PNPLWDRGKI GKVEGHQHIQ VSTSSACVWQ
    61  LAYPPVWPNL PAVPIQDFSQ KSHLPSIVVE SSEVNEESGD LHLPHEELLL LTDGEEEDAE
   121  AFFQDQSEEP GWAWSPQDPR SPLRTFNAGL SWGQDQDEED ACWILEDTAC LEATNHCPFW
   181  DSTGSRVCRS GFVEYSHLLP PNSFEGAEEE AVQTPAGVES GAASEAPGGR GCDRPRADHA
   241  APPQEAGVQC TCQHYTVREE AQKTPPADPA CPEREDSHGS GSPFKASQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LBHD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • retina: 53 nTPM
  • adrenal gland: 15 nTPM
  • liver: 11 nTPM
  • spleen: 11 nTPM
  • lymph node: 7.6 nTPM
  • small intestine: 7.4 nTPM

Single-cell type

  • cardiomyocytes: 159 nCPM
  • epicardial cells: 80 nCPM
  • adipocytes: 37 nCPM
  • erythrocyte progenitors: 26 nCPM
  • rod photoreceptor cells: 15 nCPM
  • oligodendrocytes: 10 nCPM

Immune cell

  • plasmacytoid DC: 9.9 nTPM
  • memory B-cell: 9.8 nTPM
  • NK-cell: 8.8 nTPM
  • classical monocyte: 8.6 nTPM
  • myeloid DC: 7.8 nTPM
  • memory CD8 T-cell: 7.7 nTPM

Brain region

  • choroid plexus: 7.9 nTPM
  • cerebellum: 7.6 nTPM
  • white matter: 6.1 nTPM
  • midbrain: 5.9 nTPM
  • pons: 5.8 nTPM
  • medulla oblongata: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
DepMap mean gene effect
0.01
DepMap dependency class
none

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LBHD1 as an antibody target. Whether an autoantibody or antibody against LBHD1 could matter depends on whether native LBHD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LBHD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LBHD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LBHD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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