Seroatlas · Human Serome Atlas

LBH

Protein LBH

Also known as: LBH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53QV2
Gene
LBH
Ensembl
ENSG00000213626
Chromosome
2
Canonical length
105 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Involved in negative regulation of DNA-templated transcription; positive regulation of DNA-templated transcription; and regulation of MAPK cascade. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

105 residues, UniProt reviewed canonical sequence.

>Q53QV2|LBH
     1  MSIYFPIHCP DYLRSAKMTE VMMNTQPMEE IGLSPRKDGL SYQIFPDPSD FDRCCKLKDR
    61  LPSIVVEPTE GEVESGELRW PPEEFLVQED EQDNCEETAK ENKEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LBH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
123 nTPM

Expression across tissuesHPA

Tissue

  • lung: 123 nTPM
  • thymus: 117 nTPM
  • blood vessel: 117 nTPM
  • heart muscle: 112 nTPM
  • lymph node: 110 nTPM
  • tonsil: 95 nTPM

Single-cell type

  • cone photoreceptor cells: 544 nCPM
  • vascular smooth muscle cells: 456 nCPM
  • breast myoepithelial cells: 370 nCPM
  • late spermatids: 252 nCPM
  • fallopian tube ciliated cells: 198 nCPM
  • t-cells: 170 nCPM

Immune cell

  • naive CD4 T-cell: 141 nTPM
  • naive CD8 T-cell: 125 nTPM
  • naive B-cell: 123 nTPM
  • gdT-cell: 113 nTPM
  • MAIT T-cell: 111 nTPM
  • total PBMC: 110 nTPM

Brain region

  • hypothalamus: 68 nTPM
  • medulla oblongata: 43 nTPM
  • cerebral cortex: 40 nTPM
  • choroid plexus: 33 nTPM
  • pons: 33 nTPM
  • midbrain: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0.01
gnomAD missense Z
0.59
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LBH as an antibody target. Whether an autoantibody or antibody against LBH could matter depends on whether native LBH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LBH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LBH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LBH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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