Seroatlas · Human Serome Atlas

LAT2

Linker for activation of T-cells family member 2

Also known as: HSPC046, LAB, NTAL, NTAL_HUMAN, WBSCR15, WBSCR5, WSCR5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZY6
Gene: LAT2
Ensembl: ENSG00000086730
Chromosome: 7
Canonical length: 243 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q9GZY6|LAT2
     1  MSSGTELLWP GAALLVLLGV AASLCVRCSR PGAKRSEKIY QQRSLREDQQ SFTGSRTYSL
    61  VGQAWPGPLA DMAPTRKDKL LQFYPSLEDP ASSRYQNFSK GSRHGSEEAY IDPIAMEYYN
   121  WGRFSKPPED DDANSYENVL ICKQKTTETG AQQEGIGGLC RGDLSLSLAL KTGPTSGLCP
   181  SASPEEDEES EDYQNSASIH QWRESRKVMG QLQREASPGP VGSPDEEDGE PDYVNGEVAA
   241  TEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 58 nTPM
tonsil: 53 nTPM
lymph node: 48 nTPM
spleen: 42 nTPM
appendix: 36 nTPM
lung: 18 nTPM

Single-cell type

neutrophils: 352 nCPM
mast cells: 199 nCPM
nk-cells: 148 nCPM
microglia: 142 nCPM
cdc: 132 nCPM
monocyte progenitors: 126 nCPM

Immune cell

basophil: 873 nTPM
neutrophil: 493 nTPM
classical monocyte: 277 nTPM
myeloid DC: 225 nTPM
total PBMC: 215 nTPM
naive B-cell: 192 nTPM

Brain region

white matter: 40 nTPM
medulla oblongata: 36 nTPM
spinal cord: 33 nTPM
pons: 32 nTPM
thalamus: 30 nTPM
midbrain: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SH2 domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Linker for activation of T-cells family member 2
Linker for activation of T-cells family member 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LAT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GRB2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAT2 as an antibody target. Whether an autoantibody or antibody against LAT2 could matter depends on whether native LAT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAT2 is annotated at the cell surface, where native LAT2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LAT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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