Seroatlas · Human Serome Atlas

LARGE2

Xylosyl- and glucuronyltransferase LARGE2

Also known as: FLJ35207, GYLTL1B, LARG2_HUMAN, PP5656

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3Y3
Gene: LARGE2
Ensembl: ENSG00000165905
Chromosome: 11
Canonical length: 721 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

721 residues, UniProt reviewed canonical sequence.

>Q8N3Y3|LARGE2
     1  MLPRGRPRAL GAAALLLLLL LLGFLLFGGD LGCERREPGG RAGAPGCFPG PLMPRVPPDG
    61  RLRRAAALDG DPGAGPGDHN RSDCGPQPPP PPKCELLHVA IVCAGHNSSR DVITLVKSML
   121  FYRKNPLHLH LVTDAVARNI LETLFHTWMV PAVRVSFYHA DQLKPQVSWI PNKHYSGLYG
   181  LMKLVLPSAL PAELARVIVL DTDVTFASDI SELWALFAHF SDTQAIGLVE NQSDWYLGNL
   241  WKNHRPWPAL GRGFNTGVIL LRLDRLRQAG WEQMWRLTAR RELLSLPATS LADQDIFNAV
   301  IKEHPGLVQR LPCVWNVQLS DHTLAERCYS EASDLKVIHW NSPKKLRVKN KHVEFFRNFY
   361  LTFLEYDGNL LRRELFVCPS QPPPGAEQLQ QALAQLDEED PCFEFRQQQL TVHRVHVTFL
   421  PHEPPPPRPH DVTLVAQLSM DRLQMLEALC RHWPGPMSLA LYLTDAEAQQ FLHFVEASPV
   481  LAARQDVAYH VVYREGPLYP VNQLRNVALA QALTPYVFLS DIDFLPAYSL YDYLRASIEQ
   541  LGLGSRRKAA LVVPAFETLR YRFSFPHSKV ELLALLDAGT LYTFRYHEWP RGHAPTDYAR
   601  WREAQAPYRV QWAANYEPYV VVPRDCPRYD PRFVGFGWNK VAHIVELDAQ EYELLVLPEA
   661  FTIHLPHAPS LDISRFRSSP TYRDCLQALK DEFHQDLSRH HGAAALKYLP ALQQPQSPAR
   721  G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LARGE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

placenta: 34 nTPM
pancreas: 26 nTPM
kidney: 20 nTPM
skin: 18 nTPM
salivary gland: 17 nTPM
esophagus: 16 nTPM

Single-cell type

cytotrophoblasts: 331 nCPM
breast lactating cells: 290 nCPM
syncytiotrophoblasts: 139 nCPM
migrating cytotrophoblasts: 95 nCPM
endometrial luminal cells: 45 nCPM
epididymal basal cells: 42 nCPM

Immune cell

naive B-cell: 2.1 nTPM
memory B-cell: 1.4 nTPM
MAIT T-cell: 0.5 nTPM
memory CD8 T-cell: 0.4 nTPM
NK-cell: 0.3 nTPM
gdT-cell: 0.1 nTPM

Brain region

choroid plexus: 27 nTPM
hippocampal formation: 1.9 nTPM
cerebellum: 1.3 nTPM
cerebral cortex: 0.8 nTPM
hypothalamus: 0.8 nTPM
medulla oblongata: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LARGE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

B4GAT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LARGE2 as an antibody target. Whether an autoantibody or antibody against LARGE2 could matter depends on whether native LARGE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LARGE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LARGE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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