LAPTM5

Protein identityUniProt · HPA

UniProt accession

Q13571

Gene

LAPTM5

Ensembl

ENSG00000162511

Chromosome

1

Canonical length

262 aa

Protein class

Predicted membrane proteins, Transporters

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q13571|LAPTM5
     1  MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KLSQMGYLRI
    61  ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI MDYLLCLLTL LGSYIELPAY
   121  LKLASRSRAS SSKFPLMTLQ LLDFCLSILT LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP
   181  HNQFIKMMII FSIAFITVLI FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE
   241  EALSLPSKTP EGGPAPPPYS EV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAPTM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

5

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

1,214 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.4

gnomAD pLI

0.9

gnomAD missense Z

0.49

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to leukemia inhibitory factor
• defense response to tumor cell
• Golgi to lysosome transport
• intracellular protein transport
• intrinsic apoptotic signaling pathway
• negative regulation of activated T cell proliferation
• negative regulation of autophagic cell death
• negative regulation of B cell activation
• negative regulation of interleukin-2 production
• negative regulation of T cell activation
• negative regulation of T cell receptor signaling pathway
• negative regulation of type II interferon production
• positive regulation of cytokine production involved in immune response
• positive regulation of interleukin-12 production
• positive regulation of interleukin-6 production
• positive regulation of macrophage cytokine production
• positive regulation of MAPK cascade
• positive regulation of non-canonical NF-kappaB signal transduction
• positive regulation of protein ubiquitination
• positive regulation of receptor catabolic process
• positive regulation of tumor necrosis factor-mediated signaling pathway
• positive regulation of ubiquitin-dependent protein catabolic process
• protein targeting to lysosome
• induction of programmed cell death
• negative regulation of pre-B cell receptor expression
• positive regulation of lysosomal membrane permeability

Molecular functions

• protein sequestering activity
• ubiquitin protein ligase binding

Cellular components

• cytoplasmic vesicle
• cytosol
• lysosomal membrane
• lysosome
• perinuclear region of cytoplasm
• plasma membrane
• protein-containing complex
• transport vesicle

Protein domainsUniProt · Pfam · InterPro

• Lysosomal-associated transmembrane protein 4/5
• Lysosomal-associated transmembrane protein, 4A/5
• Lysosomal-associated transmembrane transporter
• Golgi 4-transmembrane spanning transporter

KeywordsUniProt

• Lysosome
• Membrane
• Phosphoprotein
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of LAPTM5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NEDD4
• NEDD4L