LAPTM4A
Lysosomal-associated transmembrane protein 4A
Also known as: HUMORF13, KIAA0108, LAP4A_HUMAN, LAPTM4, MBNT, Mtrp
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15012
- Gene
- LAPTM4A
- Ensembl
- ENSG00000068697
- Chromosome
- 2
- Canonical length
- 233 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Golgi apparatus,Vesicles,Plasma membrane
OverviewNCBI Gene
This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
233 residues, UniProt reviewed canonical sequence.
>Q15012|LAPTM4A
1 MVSMSFKRNR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV
61 NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF
121 VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFA LFIIFKAYLI
181 NCVWNCYKYI NNRNVPEIAV YPAFEAPPQY VLPTYEMAVK MPEKEPPPPY LPALocalizationUniProt · AlphaFold · HPA
Whether an antibody against LAPTM4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 576 nTPM
Expression across tissuesHPA
Tissue
- seminal vesicle: 576 nTPM
- ovary: 486 nTPM
- endometrium: 476 nTPM
- cervix: 441 nTPM
- kidney: 430 nTPM
- adrenal gland: 426 nTPM
Single-cell type
- late spermatids: 1,853 nCPM
- extravillous trophoblasts: 1,546 nCPM
- early spermatids: 1,524 nCPM
- decidual stromal cells: 1,395 nCPM
- granulosa cells: 1,250 nCPM
- mast cells: 1,132 nCPM
Immune cell
- basophil: 741 nTPM
- total PBMC: 427 nTPM
- non-classical monocyte: 395 nTPM
- classical monocyte: 383 nTPM
- intermediate monocyte: 325 nTPM
- eosinophil: 290 nTPM
Brain region
- choroid plexus: 156 nTPM
- hypothalamus: 114 nTPM
- spinal cord: 114 nTPM
- medulla oblongata: 109 nTPM
- white matter: 107 nTPM
- thalamus: 104 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.88
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.05
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LAPTM4A as an antibody target. Whether an autoantibody or antibody against LAPTM4A could matter depends on whether native LAPTM4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LAPTM4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LAPTM4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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