Seroatlas · Human Serome Atlas

LAP3

Cytosol aminopeptidase

Also known as: AMPL_HUMAN, LAP, LAPEP, PEPS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P28838
Gene: LAP3
Ensembl: ENSG00000002549
Chromosome: 4
Canonical length: 519 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Midbody,Cytosol,Calyx,Mid piece,Principal piece
Quaternary structure: Homohexamer

OverviewNCBI Gene

Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in several cellular components, including extracellular exosome; focal adhesion; and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>P28838|LAP3
     1  MFLLPLPAAG RVVVRRLAVR RFGSRSLSTA DMTKGLVLGI YSKEKEDDVP QFTSAGENFD
    61  KLLAGKLRET LNISGPPLKA GKTRTFYGLH QDFPSVVLVG LGKKAAGIDE QENWHEGKEN
   121  IRAAVAAGCR QIQDLELSSV EVDPCGDAQA AAEGAVLGLY EYDDLKQKKK MAVSAKLYGS
   181  GDQEAWQKGV LFASGQNLAR QLMETPANEM TPTRFAEIIE KNLKSASSKT EVHIRPKSWI
   241  EEQAMGSFLS VAKGSDEPPV FLEIHYKGSP NANEPPLVFV GKGITFDSGG ISIKASANMD
   301  LMRADMGGAA TICSAIVSAA KLNLPINIIG LAPLCENMPS GKANKPGDVV RAKNGKTIQV
   361  DNTDAEGRLI LADALCYAHT FNPKVILNAA TLTGAMDVAL GSGATGVFTN SSWLWNKLFE
   421  ASIETGDRVW RMPLFEHYTR QVVDCQLADV NNIGKYRSAG ACTAAAFLKE FVTHPKWAHL
   481  DIAGVMTNKD EVPYLRKGMT GRPTRTLIEF LLRFSQDNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 178 nTPM

Expression across tissuesHPA

Tissue

liver: 178 nTPM
lymph node: 141 nTPM
appendix: 124 nTPM
kidney: 99 nTPM
lung: 95 nTPM
spleen: 89 nTPM

Single-cell type

hofbauer cells: 375 nCPM
breast lactating cells: 219 nCPM
late primary spermatocytes: 202 nCPM
vascular endothelial cells: 149 nCPM
cdc: 144 nCPM
macrophages: 137 nCPM

Immune cell

intermediate monocyte: 210 nTPM
myeloid DC: 205 nTPM
classical monocyte: 201 nTPM
non-classical monocyte: 159 nTPM
total PBMC: 136 nTPM
plasmacytoid DC: 117 nTPM

Brain region

medulla oblongata: 58 nTPM
spinal cord: 56 nTPM
white matter: 51 nTPM
thalamus: 50 nTPM
cerebellum: 42 nTPM
pons: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 1.09
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptidase M17, leucyl aminopeptidase, C-terminal
Peptidase M17, leucine aminopeptidase/peptidase B
Macro domain-like
Cytosol aminopeptidase family, catalytic domain
Peptidase M17, leucyl aminopeptidase, N-terminal
Peptidase M17, leucine aminopeptidase
Cytosol aminopeptidase family, N-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LAP3 as an antibody target. Whether an autoantibody or antibody against LAP3 could matter depends on whether native LAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LAP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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