Seroatlas · Human Serome Atlas

LANCL3

LanC-like protein 3

Also known as: FLJ42925, LANC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZV70
Gene: LANCL3
Ensembl: ENSG00000147036
Chromosome: X
Canonical length: 420 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in carbohydrate metabolic process and peptide modification. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q6ZV70|LANCL3
     1  MDTKRCFANR FDDYQGSLLA GQCEEAVAPL VTATIERILQ ELPPLGGGAE ARGATAGASA
    61  CQGGLYGGVA GVAYMLYHVS QSPLFATARE RYLRSAKRLI DACARAEEWG EPDADTRAAF
   121  LLGGAGVYAV ATLVYHALGR SDYVQPLGKF RALCAVCAPV SFLECGSDEL FVGRAGYLCA
   181  ALVLKQKLAQ EVLTPAQIKS ICQAILDSGK QYAIKKRKPF PLMYSYYGTE YLGAAHGLSS
   241  ILQMLLSYHE HLKPSDRELV WQSVDFLMEQ EQNCNWPPEL GETIERENEL VHWCHGAPGI
   301  AYLFAKAYLV SKKPQYLDTC IRCGELTWQK GLLKKGPGIC HGVAGSAYVF LLLYRLTGNS
   361  KYIYRAQRFA QFLFTEEFKA GSRVLESIYS LYEGFSGTVC FLIDLLQPNQ AEFPLFSVFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LANCL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

esophagus: 1 nTPM
colon: 0.8 nTPM
vagina: 0.8 nTPM
hypothalamus: 0.7 nTPM
retina: 0.6 nTPM
skin: 0.6 nTPM

Single-cell type

platelets: 218 nCPM
pituicytes/fscs: 178 nCPM
salivary ionocytes: 51 nCPM
retinal ganglion cells: 43 nCPM
esophageal apical cells: 30 nCPM
esophageal suprabasal cells: 24 nCPM

Immune cell

basophil: 3.8 nTPM
memory CD8 T-cell: 0.8 nTPM
gdT-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
NK-cell: 0.4 nTPM
eosinophil: 0.3 nTPM

Brain region

hypothalamus: 10 nTPM
cerebellum: 7.6 nTPM
midbrain: 5.6 nTPM
medulla oblongata: 4.4 nTPM
cerebral cortex: 4.3 nTPM
pons: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.04
gnomAD missense Z: 0.14
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LANCL3 as an antibody target. Whether an autoantibody or antibody against LANCL3 could matter depends on whether native LANCL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LANCL3 is annotated at the cell surface, where native LANCL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LANCL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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