Seroatlas · Human Serome Atlas

LANCL2

LanC-like protein 2

Also known as: GPR69B, LANC2_HUMAN, TASP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NS86
Gene
LANCL2
Ensembl
ENSG00000132434
Chromosome
7
Canonical length
450 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in negative regulation of DNA-templated transcription and positive regulation of abscisic acid-activated signaling pathway. Located in several cellular components, including cortical actin cytoskeleton; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q9NS86|LANCL2
     1  MGETMSKRLK LHLGGEAEME ERAFVNPFPD YEAAAGALLA SGAAEETGCV RPPATTDEPG
    61  LPFHQDGKII HNFIRRIQTK IKDLLQQMEE GLKTADPHDC SAYTGWTGIA LLYLQLYRVT
   121  CDQTYLLRSL DYVKRTLRNL NGRRVTFLCG DAGPLAVGAV IYHKLRSDCE SQECVTKLLQ
   181  LQRSVVCQES DLPDELLYGR AGYLYALLYL NTEIGPGTVC ESAIKEVVNA IIESGKTLSR
   241  EERKTERCPL LYQWHRKQYV GAAHGMAGIY YMLMQPAAKV DQETLTEMVK PSIDYVRHKK
   301  FRSGNYPSSL SNETDRLVHW CHGAPGVIHM LMQAYKVFKE EKYLKEAMEC SDVIWQRGLL
   361  RKGYGICHGT AGNGYSFLSL YRLTQDKKYL YRACKFAEWC LDYGAHGCRI PDRPYSLFEG
   421  MAGAIHFLSD VLGPETSRFP AFELDSSKRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LANCL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 23 nTPM
  • hippocampal formation: 21 nTPM
  • amygdala: 19 nTPM
  • basal ganglia: 18 nTPM
  • spinal cord: 15 nTPM
  • hypothalamus: 14 nTPM

Single-cell type

  • oligodendrocytes: 114 nCPM
  • oligodendrocyte progenitor cells: 89 nCPM
  • corticotrophs: 86 nCPM
  • late spermatids: 82 nCPM
  • brain excitatory neurons: 78 nCPM
  • late primary spermatocytes: 78 nCPM

Immune cell

  • T-reg: 2.6 nTPM
  • intermediate monocyte: 1.9 nTPM
  • myeloid DC: 1.9 nTPM
  • MAIT T-cell: 1.7 nTPM
  • classical monocyte: 1.5 nTPM
  • memory CD8 T-cell: 1.5 nTPM

Brain region

  • hippocampal formation: 36 nTPM
  • cerebral cortex: 32 nTPM
  • basal ganglia: 30 nTPM
  • amygdala: 27 nTPM
  • white matter: 27 nTPM
  • hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.31
gnomAD missense Z
0.77
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LANCL2 as an antibody target. Whether an autoantibody or antibody against LANCL2 could matter depends on whether native LANCL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LANCL2 is annotated at the cell surface, where native LANCL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LANCL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LANCL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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