LAD1
Ladinin-1
Also known as: LAD1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O00515
- Gene
- LAD1
- Ensembl
- ENSG00000159166
- Chromosome
- 1
- Canonical length
- 517 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Actin filaments
- Secretome location
- Secreted to extracellular matrix
OverviewNCBI Gene
The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
517 residues, UniProt reviewed canonical sequence.
>O00515|LAD1
1 MAVSRKDWSA LSSLARQRTL EDEEEQERER RRRHRNLSST TDDEAPRLSQ NGDRQASASE
61 RLPSVEEAEV PKPLPPASKD EDEDIQSILR TRQERRQRRQ VVEAAQAPIQ ERLEAEEGRN
121 SLSPVQATQK PLVSKKELEI PPRRRLSREQ RGPWALEEES LVGREPEERK KGVPEKSPVL
181 EKSSMPKKTA PEKSLVSDKT SISEKVLASE KTSLSEKIAV SEKRNSSEKK SVLEKTSVSE
241 KSLAPGMALG SGRRLVSEKA SIFEKALASE KSPTADAKPA PKRATASEQP LAQEPPASGG
301 SPATTKEQRG RALPGKNLPS LAKQGASDPP TVASRLPPVT LQVKIPSKEE EADMSSPTQR
361 TYSSSLKRSS PRTISFRMKP KKENSETTLT RSASMKLPDN TVKLGEKLER YHTAIRRSES
421 VKSRGLPCTE LFVAPVGVAS KRHLFEKELA GQSRAEPASS RKENLRLSGV VTSRLNLWIS
481 RTQESGDQDP QEAQKASSAT ERTQWGQKSD SSLDAEVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 350 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 350 nTPM
- skin: 207 nTPM
- vagina: 131 nTPM
- cervix: 97 nTPM
- duodenum: 71 nTPM
- small intestine: 70 nTPM
Single-cell type
- esophageal apical cells: 127 nCPM
- esophageal suprabasal cells: 111 nCPM
- suprabasal keratinocytes: 93 nCPM
- esophageal basal cells: 62 nCPM
- urothelial cells: 50 nCPM
- tuft cells: 46 nCPM
Immune cell
- plasmacytoid DC: 0.6 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- hypothalamus: 1.8 nTPM
- cerebral cortex: 0.9 nTPM
- amygdala: 0.5 nTPM
- basal ganglia: 0.5 nTPM
- hippocampal formation: 0.5 nTPM
- pons: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.34
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.33
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Ladinin 1
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LAD1 as an antibody target. Whether an autoantibody or antibody against LAD1 could matter depends on whether native LAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LAD1 is annotated as secreted, so native LAD1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label LAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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