Seroatlas · Human Serome Atlas

LACTBL1

Putative beta-lactamase-like 1

Also known as: BLML_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MY62
Gene
LACTBL1
Canonical length
500 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for LACTBL1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>A8MY62|LACTBL1
     1  MCPRHPEPVP LAHPLPVLKE ALEKVDQILR QAMSAPGVAA MSAVVIHNDT VLWTGNFGKK
    61  NGSDPASGAP NEYTMYRISS ISKIFPVLML YRLWEEGIVA SLDDPLERYA STFTINNPLG
   121  LASAEQQGLI LRRMASQLSG LPRRLRSTSL LWKGSTQEAL NLLKDDVLVV DPGTRCHYST
   181  LAFSLLAHVL AAHTAQGDYQ RWVSENVLEP LGMADTGFDL TPDVRARLAA GFYGSGRPAP
   241  LYDLGWYRPS GQMYSTAADL AKLAVALLGG GPRRLLRPDA AKTLLAPLLA CPGAYFANET
   301  GTPWEFHAQR GYRVVRKDGD LDGYAATFSL VPPLRLGLVL LLAGPRPPGP DLVARAYDEL
   361  LPALERALRE AEPGPAPPPT AHPFAGYFTF ANLTFYEVRA GPAGELRLRQ FGPRVEALVP
   421  PAFRTLALRH LHGRVFQLHV AHEFPCALPL GDAWLSLEAQ HGQLVNFYPL DHHGLSPGFD
   481  VPGLNTYRVL RLRGKPVFKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LACTBL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
3.6 nTPM

Expression across tissuesHPA

Tissue

  • retina: 3.6 nTPM
  • testis: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • retinal bipolar cells: 34 nCPM
  • paneth cells: 3.9 nCPM
  • epicardial cells: 2.3 nCPM
  • cone photoreceptor cells: 2.1 nCPM
  • late spermatids: 1.2 nCPM
  • late primary spermatocytes: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
1.3

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LACTBL1 as an antibody target. Whether an autoantibody or antibody against LACTBL1 could matter depends on whether native LACTBL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LACTBL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LACTBL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LACTBL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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