Seroatlas · Human Serome Atlas

LACRT

Extracellular glycoprotein lacritin

Also known as: LACRITIN, LACRT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZZ8
Gene: LACRT
Ensembl: ENSG00000135413
Chromosome: 12
Canonical length: 138 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>Q9GZZ8|LACRT
     1  MKFTTLLFLA AVAGALVYAE DASSDSTGAD PAQEAGTSKP NEEISGPAEP ASPPETTTTA
    61  QETSAAAVQG TAKVTSSRQE LNPLKSIVEK SILLTEQALA KAGKGMHGGV PGGKQFIENG
   121  SEFAQKLLKK FSLLKPWA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LACRT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 12 nTPM
thymus: 0.7 nTPM
breast: 0.5 nTPM
skin: 0.5 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

salivary acinar cells: 169 nCPM
lacrimal acinar cells: 159 nCPM
neutrophils: 53 nCPM
plasma cells: 15 nCPM
salivary duct cells: 6.1 nCPM
retinal pigment epithelial cells: 4.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 0.4 nTPM
cerebral cortex: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
pons: 0.2 nTPM
cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -0.37
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Dermcidin/Lacritin

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LACRT as an antibody target. Whether an autoantibody or antibody against LACRT could matter depends on whether native LACRT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LACRT is annotated as secreted, so native LACRT circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LACRT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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