Seroatlas · Human Serome Atlas

L3HYPDH

Trans-3-hydroxy-L-proline dehydratase

Also known as: C14orf149, FLJ25436, T3HPD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EM0
Gene: L3HYPDH
Ensembl: ENSG00000126790
Chromosome: 14
Canonical length: 354 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a dehydratase that converts trans-3-hydroxy-L-proline to delta(1)-pyrroline-2-carboxylate. This enzyme may function to degrade dietary proteins that contain trans-3-hydroxy-L-proline as well as other proteins such as collagen IV. The encoded protein can be converted to an epimerase by changing a threonine to a cysteine at a catalytic site. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q96EM0|L3HYPDH
     1  MESALAVPRL PPHDPGTPVL SVVDMHTGGE PLRIVLAGCP EVSGPTLLAK RRYMRQHLDH
    61  VRRRLMFEPR GHRDMYGAVL VPSELPDAHL GVLFLHNEGY SSMCGHAVLA LGRFALDFGL
   121  VPAPPAGTRE ARVNIHCPCG LVTAFVACED GRSHGPVRFH SVPAFVLATD LMVDVPGHGK
   181  VMVDIAYGGA FYAFVTAEKL GLDICSAKTR DLVDAASAVT EAVKAQFKIN HPDSEDLAFL
   241  YGTILTDGKD AYTKEPTTNI CVFADEQVDR SPTGSGVTAR IALQYHKGLL ELNQMRAFKS
   301  SATGSVFTGK AVREAKCGDF KAVIVEVSGQ AHYTGTASFI IEDDDPLRDG FLLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against L3HYPDH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 23 nTPM
adipose tissue: 17 nTPM
ovary: 17 nTPM
fallopian tube: 17 nTPM
lymph node: 16 nTPM
kidney: 16 nTPM

Single-cell type

adipocytes: 54 nCPM
cardiomyocytes: 41 nCPM
epicardial cells: 41 nCPM
megakaryocyte progenitors: 37 nCPM
proximal tubule cells: 37 nCPM
ependymal cells: 32 nCPM

Immune cell

myeloid DC: 5.7 nTPM
NK-cell: 5.6 nTPM
intermediate monocyte: 5.1 nTPM
classical monocyte: 3.5 nTPM
gdT-cell: 3.3 nTPM
plasmacytoid DC: 3.2 nTPM

Brain region

choroid plexus: 26 nTPM
cerebellum: 25 nTPM
medulla oblongata: 22 nTPM
white matter: 21 nTPM
midbrain: 17 nTPM
hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

hydro-lyase activity
trans-L-3-hydroxyproline dehydratase activity

Protein domainsUniProt · Pfam · InterPro

Proline racemase family
Proline racemase

KeywordsUniProt

Lyase

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads L3HYPDH as an antibody target. Whether an autoantibody or antibody against L3HYPDH could matter depends on whether native L3HYPDH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

L3HYPDH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label L3HYPDH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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