Seroatlas · Human Serome Atlas

L1TD1

LINE-1 type transposase domain-containing protein 1

Also known as: ECAT11, FLJ10884, LITD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T7N2
Gene: L1TD1
Ensembl: ENSG00000240563
Chromosome: 1
Canonical length: 865 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable single-stranded RNA binding activity. Predicted to be involved in retrotransposition. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

865 residues, UniProt reviewed canonical sequence.

>Q5T7N2|L1TD1
     1  MSDVSTSVQS KFARLAKKKE NITYMKREQL TETDKDIAPV LDLKCKDVSA IMNKFKVLME
    61  IQDLMFEEMR ETLKNDLKAV LGGKATIPEV KNSENSSSRT EFQQIINLAL QKTGMVGKIE
   121  GENSKIGDDN ENLTFKLEVN ELSGKLDNTN EYNSNDGKKL PQGESRSYEV MGSMEETLCN
   181  IDDRDGNRNV HLEFTERESR KDGEDEFVKE MREERKFQKL KNKEEVLKAS REEKVLMDEG
   241  AVLTLVADLS SATLDISKQW SNVFNILREN DFEPKFLCEV KLAFKCDGEI KTFSDLQSLR
   301  KFASQKSSVK ELLKDVLPQK EEINQGGRKY GIQEKRDKTL IDSKHRAGEI TSDGLSFLFL
   361  KEVKVAKPEE MKNLETQEEE FSELEELDEE ASGMEDDEDT SGLEEEEEEP SGLEEEEEEE
   421  ASGLEEDEAS GLEEEEEQTS EQDSTFQGHT LVDAKHEVEI TSDGMETTFI DSVEDSESEE
   481  EEEGKSSETG KVKTTSLTEK KASRRQKEIP FSYLVGDSGK KKLVKHQVVH KTQEEEETAV
   541  PTSQGTGTPC LTLCLASPSK SLEMSHDEHK KHSHTNLSIS TGVTKLKKTE EKKHRTLHTE
   601  ELTSKEADLT EETEENLRSS VINSIREIKE EIGNLKSSHS GVLEIENSVD DLSSRMDILE
   661  ERIDSLEDQI EEFSKDTMQM TKQIISKERQ RDIEERSRSC NIRLIGIPEK ESYENRAEDI
   721  IKEIIDENFA ELKKGSSLEI VSACRVPSKI DEKRLTPRHI LVKFWNSSDK EKIIRASRER
   781  REITYQGTRI RLTADLSLDT LDARSKWSNV FKVLLEKGFN PRILYPAKMA FDFRGKTKVF
   841  LSIEEFRDYV LHMPTLRELL GNNIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against L1TD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

placenta: 11 nTPM
testis: 5.4 nTPM
colon: 5 nTPM
appendix: 4.4 nTPM
lung: 1.4 nTPM
rectum: 1.1 nTPM

Single-cell type

cytotrophoblasts: 162 nCPM
undifferentiated spermatogonia: 130 nCPM
migrating cytotrophoblasts: 59 nCPM
tuft cells: 58 nCPM
extravillous trophoblasts: 29 nCPM
syncytiotrophoblasts: 25 nCPM

Immune cell

non-classical monocyte: 5.1 nTPM
intermediate monocyte: 0.3 nTPM
memory B-cell: 0.2 nTPM
myeloid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 6.1 nTPM
white matter: 4.4 nTPM
basal ganglia: 4.2 nTPM
pons: 3.8 nTPM
amygdala: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: -0.89
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads L1TD1 as an antibody target. Whether an autoantibody or antibody against L1TD1 could matter depends on whether native L1TD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

L1TD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label L1TD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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