Seroatlas · Human Serome Atlas

KYAT3

Kynurenine--oxoglutarate transaminase 3

Also known as: CCBL2, KAT3, KAT3_HUMAN, KATIII, RBM1, RP11-82K18.3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6YP21
Gene: KYAT3
Ensembl: ENSG00000137944
Chromosome: 1
Canonical length: 454 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Cytokinetic bridge,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>Q6YP21|KYAT3
     1  MFLAQRSLCS LSGRAKFLKT ISSSKILGFS TSAKMSLKFT NAKRIEGLDS NVWIEFTKLA
    61  ADPSVVNLGQ GFPDISPPTY VKEELSKIAA IDSLNQYTRG FGHPSLVKAL SYLYEKLYQK
   121  QIDSNKEILV TVGAYGSLFN TIQALIDEGD EVILIVPFYD CYEPMVRMAG ATPVFIPLRS
   181  KPVYGKRWSS SDWTLDPQEL ESKFNSKTKA IILNTPHNPL GKVYNREELQ VIADLCIKYD
   241  TLCISDEVYE WLVYSGNKHL KIATFPGMWE RTITIGSAGK TFSVTGWKLG WSIGPNHLIK
   301  HLQTVQQNTI YTCATPLQEA LAQAFWIDIK RMDDPECYFN SLPKELEVKR DRMVRLLESV
   361  GLKPIVPDGG YFIIADVSLL DPDLSDMKNN EPYDYKFVKW MTKHKKLSAI PVSAFCNSET
   421  KSQFEKFVRF CFIKKDSTLD AAEEIIKAWS VQKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KYAT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 31 nTPM
kidney: 29 nTPM
pancreas: 28 nTPM
breast: 28 nTPM
ovary: 27 nTPM
liver: 26 nTPM

Single-cell type

syncytiotrophoblasts: 129 nCPM
sertoli cells: 120 nCPM
cytotrophoblasts: 110 nCPM
migrating cytotrophoblasts: 101 nCPM
neutrophils: 97 nCPM
pancreatic acinar cells: 87 nCPM

Immune cell

myeloid DC: 16 nTPM
T-reg: 16 nTPM
classical monocyte: 12 nTPM
NK-cell: 11 nTPM
MAIT T-cell: 11 nTPM
memory CD4 T-cell: 11 nTPM

Brain region

choroid plexus: 18 nTPM
cerebellum: 14 nTPM
cerebral cortex: 13 nTPM
midbrain: 13 nTPM
hypothalamus: 13 nTPM
pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KYAT3 as an antibody target. Whether an autoantibody or antibody against KYAT3 could matter depends on whether native KYAT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KYAT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KYAT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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