Seroatlas · Human Serome Atlas

KYAT1

Kynurenine--oxoglutarate transaminase 1

Also known as: CCBL1, GTK, KAT1_HUMAN, KATI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16773
Gene
KYAT1
Ensembl
ENSG00000171097
Chromosome
9
Canonical length
422 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q16773|KYAT1
     1  MAKQLQARRL DGIDYNPWVE FVKLASEHDV VNLGQGFPDF PPPDFAVEAF QHAVSGDFML
    61  NQYTKTFGYP PLTKILASFF GELLGQEIDP LRNVLVTVGG YGALFTAFQA LVDEGDEVII
   121  IEPFFDCYEP MTMMAGGRPV FVSLKPGPIQ NGELGSSSNW QLDPMELAGK FTSRTKALVL
   181  NTPNNPLGKV FSREELELVA SLCQQHDVVC ITDEVYQWMV YDGHQHISIA SLPGMWERTL
   241  TIGSAGKTFS ATGWKVGWVL GPDHIMKHLR TVHQNSVFHC PTQSQAAVAE SFEREQLLFR
   301  QPSSYFVQFP QAMQRCRDHM IRSLQSVGLK PIIPQGSYFL ITDISDFKRK MPDLPGAVDE
   361  PYDRRFVKWM IKNKGLVAIP VSIFYSVPHQ KHFDHYIRFC FVKDEATLQA MDEKLRKWKV
   421  EL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KYAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 21 nTPM
  • cerebral cortex: 14 nTPM
  • basal ganglia: 13 nTPM
  • cerebellum: 13 nTPM
  • skeletal muscle: 12 nTPM
  • liver: 12 nTPM

Single-cell type

  • podocytes: 80 nCPM
  • choroid plexus epithelial cells: 78 nCPM
  • bergmann glia: 55 nCPM
  • brain inhibitory neurons: 48 nCPM
  • brain excitatory neurons: 43 nCPM
  • astrocytes: 38 nCPM

Immune cell

  • memory B-cell: 7.7 nTPM
  • T-reg: 7 nTPM
  • naive CD8 T-cell: 6.8 nTPM
  • memory CD8 T-cell: 6.1 nTPM
  • naive CD4 T-cell: 5.9 nTPM
  • memory CD4 T-cell: 5.8 nTPM

Brain region

  • white matter: 24 nTPM
  • cerebral cortex: 17 nTPM
  • basal ganglia: 15 nTPM
  • medulla oblongata: 15 nTPM
  • cerebellum: 15 nTPM
  • thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KYAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KYAT1 as an antibody target. Whether an autoantibody or antibody against KYAT1 could matter depends on whether native KYAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KYAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KYAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KYAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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