KRTDAP
Keratinocyte differentiation-associated protein
Also known as: KDAP, KTDAP_HUMAN, UNQ467
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P60985
- Gene
- KRTDAP
- Ensembl
- ENSG00000188508
- Chromosome
- 19
- Canonical length
- 99 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>P60985|KRTDAP
1 MKIPVLPAVV LLSLLVLHSA QGATLGGPEE ESTIENYASR PEAFNTPFLN IDKLRSAFKA
61 DEFLNWHALF ESIKRKLPFL NWDAFPKLKG LRSATPDAQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KRTDAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 7,414 nTPM
Expression across tissuesHPA
Tissue
- skin: 7,414 nTPM
- vagina: 2,041 nTPM
- cervix: 1,599 nTPM
- breast: 380 nTPM
- salivary gland: 229 nTPM
- esophagus: 132 nTPM
Single-cell type
- suprabasal keratinocytes: 5,941 nCPM
- esophageal apical cells: 753 nCPM
- late spermatids: 668 nCPM
- esophageal suprabasal cells: 414 nCPM
- early spermatids: 170 nCPM
- basal keratinocytes: 153 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 1.6 nTPM
- cerebral cortex: 1.2 nTPM
- pons: 0.6 nTPM
- choroid plexus: 0.4 nTPM
- hypothalamus: 0.3 nTPM
- medulla oblongata: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.91
- gnomAD pLI
- 0.08
- gnomAD missense Z
- 0.17
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Keratinocyte differentiation-associated protein
- Keratinocyte differentiation-associated
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KRTDAP as an antibody target. Whether an autoantibody or antibody against KRTDAP could matter depends on whether native KRTDAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KRTDAP is annotated as secreted, so native KRTDAP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label KRTDAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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