Seroatlas · Human Serome Atlas

KRTCAP3

Keratinocyte-associated protein 3

Also known as: KCP3, KCP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53RY4
Gene: KRTCAP3
Ensembl: ENSG00000157992
Chromosome: 2
Canonical length: 240 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q53RY4|KRTCAP3
     1  MRRCSLCAFD AARGPRRLMR VGLALILVGH VNLLLGAVLH GTVLRHVANP RGAVTPEYTV
    61  ANVISVGSGL LSVSVGLVAL LASRNLLRPP LHWVLLALAL VNLLLSVACS LGLLLAVSLT
   121  VANGGRRLIA DCHPGLLDPL VPLDEGPGHT DCPFDPTRIY DTALALWIPS LLMSAGEAAL
   181  SGYCCVAALT LRGVGPCRKD GLQGQLEEMT ELESPKCKRQ ENEQLLDQNQ EIRASQRSWV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTCAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

pancreas: 54 nTPM
stomach: 51 nTPM
salivary gland: 51 nTPM
colon: 44 nTPM
small intestine: 43 nTPM
duodenum: 42 nTPM

Single-cell type

gastric progenitor cells: 236 nCPM
breast lactating cells: 217 nCPM
enteric transient amplifying cells: 197 nCPM
enteric stem cells: 191 nCPM
paneth cells: 174 nCPM
enterocytes: 158 nCPM

Immune cell

MAIT T-cell: 6.8 nTPM
naive CD4 T-cell: 6.6 nTPM
naive B-cell: 6.5 nTPM
memory CD4 T-cell: 5.7 nTPM
memory B-cell: 4.5 nTPM
T-reg: 4.4 nTPM

Brain region

cerebellum: 11 nTPM
white matter: 8.8 nTPM
medulla oblongata: 7.9 nTPM
pons: 7.5 nTPM
choroid plexus: 7.4 nTPM
cerebral cortex: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTCAP3 as an antibody target. Whether an autoantibody or antibody against KRTCAP3 could matter depends on whether native KRTCAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTCAP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTCAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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