Seroatlas · Human Serome Atlas

KRTAP7-1

Keratin-associated protein 7-1

Also known as: KAP7.1, KRA71_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IUC3
Gene
KRTAP7-1
Ensembl
ENSG00000274749
Chromosome
21
Canonical length
87 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

87 residues, UniProt reviewed canonical sequence.

>Q8IUC3|KRTAP7-1
     1  MTRYFCCGSY FPGYPIYGTN FHGTFRATPL NCVVPLGSPL NYGCGCNGYS SLGYSFGGSN
    61  INNLGGCYGG SFYRPWGSGS GFGYSTY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP7-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • skin: 23 nTPM
  • salivary gland: 0.8 nTPM
  • adipose tissue: 0.2 nTPM
  • testis: 0.1 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • early primary spermatocytes: 0.1 nCPM
  • early spermatids: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • T-reg: 0.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • pons: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • thalamus: 0.2 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Keratin-associated protein 7
  • KRTAP type 7 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP7-1 as an antibody target. Whether an autoantibody or antibody against KRTAP7-1 could matter depends on whether native KRTAP7-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP7-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP7-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP7-1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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