Seroatlas · Human Serome Atlas

KRTAP5-8

Keratin-associated protein 5-8

Also known as: KRA58_HUMAN, KRTAP5-2, KRTAP5.8, UHSKerB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75690
Gene
KRTAP5-8
Ensembl
ENSG00000241233
Chromosome
11
Canonical length
187 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be a structural constituent of skin epidermis. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

187 residues, UniProt reviewed canonical sequence.

>O75690|KRTAP5-8
     1  MGCCGCSGGC GSGCGGCGSG CGGCGSSCCV PICCCKPVCC CVPACSCSSC GSCGGSKGGR
    61  GSCGGSKGDC GSCGGSKGGC GSCGCSQCSC YKPCCCSSGC GSSCCQSSCC KPCCSQSSCC
   121  KPCSCSSGCG SSCCQSSCCK PCCSQSSCCK PCCCSSGCGS SCCQSSCCKP CCSQSSCCVP
   181  ICCQCKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP5-8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
6.9 nTPM

Expression across tissuesHPA

Tissue

  • skin: 6.9 nTPM
  • kidney: 5.7 nTPM
  • testis: 1.4 nTPM
  • epididymis: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • urinary bladder: 0.5 nTPM

Single-cell type

  • epididymal clear cells: 12 nCPM
  • renal collecting duct intercalated cells: 2.8 nCPM
  • respiratory ionocytes: 2.5 nCPM
  • urothelial cells: 2.3 nCPM
  • epididymal principal cells: 0.8 nCPM
  • late spermatids: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.6 nTPM
  • basal ganglia: 1 nTPM
  • hippocampal formation: 0.9 nTPM
  • medulla oblongata: 0.9 nTPM
  • pons: 0.9 nTPM
  • thalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.89
gnomAD pLI
0.1
gnomAD missense Z
-0.32
DepMap mean gene effect
0.1
DepMap dependency class
none

OntologyGO

Molecular functions

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP5-8 as an antibody target. Whether an autoantibody or antibody against KRTAP5-8 could matter depends on whether native KRTAP5-8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP5-8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP5-8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP5-8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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