Seroatlas · Human Serome Atlas

KRTAP5-4

Keratin-associated protein 5-4

Also known as: KRA54_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6L8H1
Gene
KRTAP5-4
Canonical length
288 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for KRTAP5-4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q6L8H1|KRTAP5-4
     1  MGCCGCSGGC GSGCGGCGSG CGGCGSGCGG CGSGCGGCGS GCGGCGSSCC VPICCCKPVC
    61  CCVPACSCSS CGSCGGSKGG YGSCGGSKGG CVSCGGSKGG CGSCGGSKGG CGSCGGSKGG
   121  CGSCGGSKGG CVSCGGSKGG CGSCGGSKGG CVSCGGSKGG CGSCGGSKGG CGSCGGSKGG
   181  CGSCGGSKGG CGSCGCSQCS CCKPCCCSSG CGSSCCQSSC CKPCCSSSGC GSSCCQSSCC
   241  KPYCCQSSCC KPCCSSSGCG SSCCQSSCCN PCCSQSSCCV PVCCQCKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP5-4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
4.2 nTPM

Expression across tissuesHPA

Tissue

  • skin: 4.2 nTPM
  • skeletal muscle: 0.2 nTPM
  • pituitary gland: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0.02
gnomAD missense Z
-0.85

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP5-4 as an antibody target. Whether an autoantibody or antibody against KRTAP5-4 could matter depends on whether native KRTAP5-4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP5-4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP5-4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP5-4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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