Seroatlas · Human Serome Atlas

KRTAP12-4

Keratin-associated protein 12-4

Also known as: KR124_HUMAN, KRTAP12.4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60329
Gene
KRTAP12-4
Ensembl
ENSG00000212933
Chromosome
21
Canonical length
112 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>P60329|KRTAP12-4
     1  MCHTSHSSGC PMACPGSPCC VPSTCYPPEG YGTSCCCSAP CVALLCRPLC GVSTCCQPAC
    61  CVPSPCQVAC CVPVSCKPVL CVASFCPTSG CCQPFCPTLV YRPVTWSTPT GC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP12-4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • skin: 0.5 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 0.9 nTPM
  • basal ganglia: 0.6 nTPM
  • medulla oblongata: 0.3 nTPM
  • thalamus: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • hypothalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.21
DepMap mean gene effect
-0.13
DepMap dependency class
selective

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP12-4 as an antibody target. Whether an autoantibody or antibody against KRTAP12-4 could matter depends on whether native KRTAP12-4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP12-4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP12-4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP12-4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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